| Titre : |
Peptides build a 3D regenerative matrix |
| Type de document : |
texte imprimé |
| Auteurs : |
Luis J. Cruz, Auteur ; Carmen Gutierrez, Auteur ; Cristina Caniego, Auteur ; Isabelle M. Ramos, Auteur |
| Année de publication : |
2012 |
| Article en page(s) : |
p. 99-102 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Antiâge
Cosmétiques
Peau -- Soins et hygiène
Peptides
Régénération (biologie)
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
One of the main effects of ageing on skin is the reduction on its ability to selfregenerate and create new extracellular matrix (ECM). This has an impact on the production of key structural proteins, such as collagen, but also on proteoglicans, which play a role on cellular signalling.
This paper presents the results on the activity of a combination of synthetic peptides whose structures have been specifically designed to reorganise into the skin to build up a three-dimensional polymeric net that is completely biocompatible. This net not only provides a structural support to the skin helping the anchoring of cells, but also activates cellular regeneration processes. Moreover, it is able to activate intracellular signals that stimulate the proliferation and differentiation of skin cells, activating synthesis of extracellular proteins. Therefore, this specific combination of peptides constitutes the scaffold to create a structure that behaves like the extracellular matrix itself. |
| Note de contenu : |
- TECHNOLOGY DESCRIPTION
- METHODOLOGY : Microarray (DNA chip) - Characterisation of formed structures. Scanning electron microscopy (SEM). Cell proliferation studies - Affinity assay for fibroblasts - Fibroblasts binding studies by SEM - Increase of collagen I and VI formation by fluorescence microscopy - Increase of collagen I biosynthesis - Evaluation of the anti-wrinkle and of the re-densifying effect of TRP an in vivo test |
| En ligne : |
https://drive.google.com/file/d/187eJB2q2d-0OHO27qrPEeO0lVvqEIcuC/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=15796 |
in PERSONAL CARE EUROPE > Vol. 5, N° 4 (09/2012) . - p. 99-102
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