| Titre : |
Coenzyme Q10 enhances dermal elastin expression, inhibits IL-1α production and melanin synthesis in vitro |
| Type de document : |
texte imprimé |
| Auteurs : |
M. Zhang, Auteur ; L. Dang, Auteur ; F. Guo, Auteur ; W. Zhao, Auteur ; R. Zhao, Auteur |
| Année de publication : |
2012 |
| Article en page(s) : |
p. 273-279 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Agents de blanchiment
Anti tyrosinase
Antiâge
Antioxydants
Elastine
Mélanine
Peau
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Coenzyme Q10 (CoQ10) is a well-known antioxidant and has been used in many skincare products for anti-ageing purpose. However, the molecular mechanisms of CoQ10 function in skin cells are not fully understood. In this paper, we compared the effects of CoQ10 on primary human dermal fibroblasts from three individuals, including adult. We demonstrated that CoQ10 treatment promoted proliferation of fibroblasts, increased type IV collagen expression and reduced UVR-induced matrix metalloproteinases-1 (MMP-1) level in embryonic and adult cells. In addition, CoQ10 treatment increased elastin gene expression in cultured fibroblasts and significantly decreased UVR-induced IL-1α production in HaCat cells. Taken together, CoQ10 presented anti-ageing benefits against intrinsic ageing as well as photo damage. Interestingly, CoQ10 was able to inhibit tyrosinase activity, resulting in reduced melanin content in B16 cells. Thus, CoQ10 may have potential depigmentation effects for skincare. |
| Note de contenu : |
- MATERIALS AND METHODS : Cell culture - Cell proliferation assay - RNA extraction and QPCR - CoQ10 emulsion- UV irradiation - Intracellular ROS assay - Enzyme linked immunosorbent assay (ELISA) - Melanin assay, tyrosinase activity measurement and DOPA staining - Statistical analysis
- RESULTS : CoQ10 han anti-ageing effects against multiple ageing processes - CoQ10 protects cell from UV irradiation induced damage - CoQ10 reduces melanin synthesis |
| DOI : |
10.1111/j.1468-2494.2012.00713.x |
| En ligne : |
http://onlinelibrary.wiley.com/doi/10.1111/j.1468-2494.2012.00713.x |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=15038 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 34, N° 3 (06/2012) . - p. 273-279
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