[article]
| Titre : |
Development of self-dissolving microneedles consisting of hyaluronic acid as an anti-wrinkle treatment |
| Type de document : |
document électronique |
| Auteurs : |
Yukiko Matsunaga, Auteur ; Shigeyoshi Fujiwara, Auteur ; Yuichiro Mori, Auteur ; Akiko Miyake, Auteur ; Haruyo Yamanishi, Auteur ; Madoka Kage, Auteur ; Yoshihiro Tokudome, Auteur ; Fumie Hashimoto, Auteur ; Takeshi Hariya, Auteur |
| Année de publication : |
2012 |
| Article en page(s) : |
p. 73-78 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Antiâge:Antirides
Cosmétiques
Hyaluronique, acideL'acide hyaluronique est un type de polysaccharide (plus précisément une glycosaminoglycane) non fixé à une protéine centrale et largement réparti parmi les tissus conjonctifs, épithéliaux et nerveux animaux.
Il se trouve notamment dans l'humeur vitrée et le liquide synovial. Il est l'un des principaux composants de la matrice extracellulaire ainsi que de certaines mucoprotéines lorsqu'il est associé à une fraction protéique.
Depuis les années 1990, il est très utilisé dans divers dispositifs médicaux, médicamenteux et cosmétiques (présenté dans ce dernier cas comme "antistatique, humectant, hydratant, conditionneur cutané, anti-âge, etc."), bénéficiant d'un effet de mode grandement soutenu par une large publicité commerciale.
Contribuant de façon significative à la prolifération et à la migration des cellules, l'acide hyaluronique est aussi impliqué dans la progression de certains cancers. (Wikipedia)
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Hyaluronic acid, a nonsulfated glycosaminoglycans, plays a key role in water retention in the extracellular matrix. Quantitative deficiency of hyaluronic acid in the skin promotes the signs of aging and therefore supplementation of hyaluronic acid is essential to facilitate skin rejuvenation. Unfortunately, hyaluronic acid does not readily enter cutaneous tissue by passive transport because of its high molecular weight. However, self-dissolving microneedles, which are needle-shaped structures designed to pierce the stratum corneum, can be used to deliver agents to the stratum corneum or epidermis and should be able to deliver hyaluronic acid.
In this study, we developed self-dissolving microneedles composed of hyaluronic acid for cosmetic use. Microscopic examination demonstrated that the tip of these hyaluronic acid microneedles reached the lower layer of the stratum corneum. Addition of hyaluronic acid to keratinocytes promoted celle proliferation and induced upregulation of profilaggrin gene expression. Hyaluronic acid synthase 1 mRNA was also upregulated by addition of hyaluronic aid to fibroblasts. Successive applications of self-dissolving microneedles to crow's feet for 4 weeks resulted in significant improvements in wrinkle formation and skin elasticity.
These findings suggest that introduction of hyaluronic acid into the stratum corneum with microneedles may be an effective approach for cosmetic improvement of wrinkles. Self-dissolving microneedles are also expected to be effective for transdermal delivery of other cosmetically active agents. |
| Note de contenu : |
- EXPERIMENTAL : Materials - Microscopic study - Cell culture and real-time quantitative PCR - Evaluation of self-dissolving microneedles as an anti-wrinkle agent - Statistical analysis
- RESULTS AND DISCUSSION : Overview of microneedles - Microneedles penetrate the stratum corneum - Hyalunonic acid promotes proliferation and induces upregulation of profilaggrin in keratinocytes - Hyaluronic acid synthetase 1 mRNA is upregulated by hyaluronic acid addition in fibroblasts - Successive applications of self-dissolving microneedles markedly improves wrinkles |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=14955 |
in IFSCC MAGAZINE > Vol. 15, N° 2 (04-05-06/2012) . - p. 73-78
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