[article]
| Titre : |
Basics on skin barrier function |
| Type de document : |
texte imprimé |
| Auteurs : |
Rachida Nachat-Kappes, Auteur ; Jean-Yves Berthon, Auteur |
| Année de publication : |
2013 |
| Article en page(s) : |
p. 98-104 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Barrière cutanée
Dermatologie
Peau -- Anatomie et histologie
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Our skin ensures a vital barrier between the body and the environment. It prevents dehydration, limits penetration of exogenous substances and protects from mechanical stress. The stratum corneum corresponds to the outermost layer of the epidermis and is largely responsible for the barrier function establishment.
Until the seventies, the stratum corneum, which is composed of dead and flattened 'mummified' cells called corneocytes, was thought to be biologically inert. ln the late seventies and in the eighties emerged the important concept of barrier function with the model of the 'brick wall' proposed by Peter Elias. In this model, the corneocytes were the bricks, embedded within an intercellular lipid substance, which was the mortar, considered responsible for Cell cohesion. Since then many other actors have been found to contribute significantly to the formation of the epidermal barrier.
Among these factors, tight junctions, cohesion structures including desmosomes and corneodesmosomes, scaffolding proteins (involucrin/envoplakin/ periplakin), filaggrin, proteases, proteases inhibitors and antimicrobial peptides all play an important role in maintaining barrier function.
This review will cover all these components and how important they are to provide adequate barrier function. Thus, we will show how sophisticated is the cutaneous barrier function and that a better understanding of how it takes place, is essential to develop new cosmetic actives with skin-barrier reinforcing properties. |
| Note de contenu : |
- STRATUM CORNEUM STRUCTURE AND FUNCTION : The cornified envelope - The antimicrobial defences of the skin
- PH
- Antimicrobial peptides - Skin microbiome
- LAMELLAR BODIES : KEY COMPONENTS OF THE BARRIER FUNCTION : SC extracellular lipids composition and organisation - Proteases and protease inhibitors - Adherens junctions and tight junctions - (Corneo)-desmosomes
- SKIN HYDRATION : Natural moisturising factor
- Composition
- Origin of NMF
- AQUAPORINS |
| En ligne : |
https://drive.google.com/file/d/1_QkzVqSmxUyowMPjIcn1WZWIDs1JcQUI/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=19887 |
in PERSONAL CARE EUROPE > Vol. 6, N° 5 (11/2013) . - p. 98-104
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Basics on skin barrier function in PERSONAL CARE EUROPE, Vol. 6, N° 5 (11/2013)
