| Titre : |
Genetic integrity for a rejuvenated skin look |
| Type de document : |
texte imprimé |
| Auteurs : |
Marta Rull, Auteur ; Cristina Davi, Auteur ; Elena Cañadas, Auteur ; Wim Van Den Nest, Auteur ; Raquel Delgado, Auteur |
| Année de publication : |
2013 |
| Article en page(s) : |
p. 61-66 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
ADN -- Réparation
Antiâge:Antirides
Cosmétiques
Hexapeptides
Peau -- Soins et hygiène
Protection cutanée
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
The daily exposure to DNA-damaging agents leads to errors that accumulate year by year as the natural repair mechanisms become less active when ageing. Among the agents that help to delete these undesired changes, FOX03a is highlighted as an essential transcriptional factor that regulates the expression of genes implied in the repair and removal of genetic errors, depending on the severity. FOX03a is then vital to maintain genetic integrity.
Acetyl hexapeptide-51 amide is an innovative peptide that stimulates the same natural DNA-repair pathways as FOX03a, being able to activate the FOX03a responsive elements by 1.9 times and raise the DNA-repair pathways by 2.7 times. Besides, it protects from UV radiation and pollution, in vitro increasing cellular viability and decreasing the induced damage, and in vivo reducing UV-induced damage by 16.6%, at 2% peptide solution. Additionally, it also proved to in vitro diminish the number of senescent cells by 64.6%, which means 11 years of cellular rejuvenation.
Thus, Juvefoxo peptide acts as a guardian of genetic integrity that helps to repair or remove genetic errors that can result in a skin worsening even at a macroscopic level. This hexapeptide rejuvenates and improves skin aspect, enhancing natural repairing mechanisms and raising protection from daily damaging agents. |
| Note de contenu : |
- NATURAL DNA REPAIRING MECHANISMS
- FOXO TRANSCRIPTIONAL FACTORS AND LONGEVITY
- MATERIALS AND METHODS : Activation of FOXO3a responsive elements - DNA-repair pathways activation - Photoprotection efficacy - DNA-protective effect against photoactivated BaP - Reverting cellular senescence - In vivo repair of UV-induced DNA damage
- RESULTS AND DISCUSSION : Activation of FOXO3a responsive elements - DNA-repair pathways activation - Photoprotection efficacy - DNA-protective effect against photoactivated BaP - Reverting cellular senescence - In vivo repair of UV-induced DNA damage |
| En ligne : |
https://drive.google.com/file/d/1pYCJHClrtfJa4GpA_Ur9J79B_mov4ALE/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=19881 |
in PERSONAL CARE EUROPE > Vol. 6, N° 5 (11/2013) . - p. 61-66
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Genetic integrity for a rejuvenated skin look in PERSONAL CARE EUROPE, Vol. 6, N° 5 (11/2013)
