| Titre : |
In vivo anti-aging efficacy of a cyclic peptide composition |
| Type de document : |
document électronique |
| Auteurs : |
Ruediger Graf, Auteur ; Karl-August Reiffen, Auteur ; Soheila Anzali, Auteur ; Ulrike Heinrich, Auteur ; Hagen Tronnier, Auteur ; Hansjürgen Driller, Auteur ; Frank Pfluecker, Auteur |
| Année de publication : |
2012 |
| Article en page(s) : |
p. 23-27 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Antiâge:Antirides
Intégrine
Matrice extracellulaire
Peptides cycliques
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Aging affects the composition and morphological structure of the different compartments of the skin. Integrins, as an important family of transmembrane receptors, play a key role in cell-matrix interactions and are involved in cell signaling. Binding of specific ligands within the extracellular matrix to these receptors is a crucial step to maintain a vital tissue structure. For this reason a selective cyclic peptide containing an arginine-glycine-aspartic acid (RGD) sequence was designed for cosmetic applications.
The objective of the present work was to evaluate the binding efficiency of different RGD peptides to specific integrins. The cyclic RGD peptide was tested in a placebo-controlled study with human volunteers with respect to its anti-aging efficacy in vivo. The results of the ligand inhibition assay with immobilized integrins clearly demonstrated that only the cyclic conformation of the RGD motif motively binds to the integrin receptors In terms of anti-aging properties, this in vivo trial confirmed the results of previous in vitro investigations where a positive effect on wrinkle reduction was observed. Our present work again supports the hypothesis that this specific RGD peptide composition successfully mimics the biological function of extracellular matrix proteins by activating signaling pathways and targets involved in the prevention of aging. |
| Note de contenu : |
- EXPERIMENTAL : Ligand inhibition assay with immobilized integrins - Statistical evaluation of the in vivo data
- RESULTS AND DISCUSSION : Ligand inhibition assay - In vivo volunteer study : impact on wrinkle volume and anti-aging efficacy |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=13671 |
in IFSCC MAGAZINE > Vol. 15, N° 1 (01-02/2012) . - p. 23-27
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