[article]
| Titre : |
An innovative, rapid, qualitative and quantitative approach to the epidermal barrier function with in vivo confocal laser scanning microscopy |
| Type de document : |
texte imprimé |
| Auteurs : |
Anne Isabel Guzman, Auteur ; David Boudier, Auteur ; Josselin Breugnot, Auteur ; Delphine Rondeau, Auteur ; Maud Le Guillou, Auteur ; Brigitte Closs, Auteur |
| Année de publication : |
2013 |
| Article en page(s) : |
p. 157-163 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Barrière cutanée
Cosmétiques
Evaluation
Hydratation
Imagerie médicale
Imagerie numérique
Microscopie confocale à balayage laser
Peau -- Soins et hygiène
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
The barrier function of the skin is essential for maintaining the hydration and physical properties of skin tissue. Its state can be assessed using noninvasive instrumental methods widely used in cosmetics, such as the Tewameter®. This method is very simple to use but does not provide information on the state of the skin, in particular on the state of the stratum corneum and its cellular organization, and does not visualize the skin surface. However, many noninvasive medical imaging techniques used on the skin provide more precise information on this organ.
In the work reported here, we show that modeling based on acquisitions from in vivo confocal laser scanning microscopy provides high resolution digital images that can be used to assess the state of the skin surface and the integrity of the barrier function. The numerical results obtained correlate well with those obtained using the Tewameter® and therefore validate this qualitative, rapid and quantitative approach to the assessment of barrier function.
This novel approach was used to screen and assess natural cosmetic active ingredients in order to determine their effect on restoration of the barrier function of the skin. |
| Note de contenu : |
- EXPERIMENTAL : Measuring TEWL - Confocal microscopy acquisitions - Image processing and programming - Study of correlation
- RESULTS : Measurement of transepidermal water loss - Quantitative confocal microscopy study - Changes in cell organization over time - Correlation between transepidermal water loss and cellular organization
- DISCUSSION : Image processing and programming - Quantification of images by experts |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=19304 |
in IFSCC MAGAZINE > Vol. 16, N° 3 (07-08-09/2013) . - p. 157-163
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