Senolytic science : plant extract for well-ageing / Leithe Budel in GLOBAL PERSONAL CARE, Vol. 25, N° 4 (04/2024)  

[article]  inGLOBAL PERSONAL CARE > Vol. 25, N° 4 (04/2024) . - p. 117-123 Titre : Senolytic science : plant extract for well-ageing Type de document : texte imprimé Auteurs : Leithe Budel, Auteur ; François Paul, Auteur Année de publication : 2024 Article en page(s) : p. 117-123 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge Cosmétiques Dermo-cosmétologie Epilobium fleischeri Extraits de plantes:Extraits (pharmacie) Peau -- Soins et hygiène Sénolyse Index. décimale : 668.5 Parfums et cosmétiques Résumé : DSM-Firmenich reveals the findings of research that shows how a Epilobium fleischeri extract can selectively clear senescent cells – so-called 'zombie' cells - from the skin. Senescence cells are seen as fundamental drivers of tissue ageing. Senescent 'zombie cells' accumulate with age and cause damage through damaging secretions. Eliminating these cells is a revolutionary approach to restoring youthful skin. Research by experts in ageing has revealed that Epilobium fleischeri extract is a natural botanical senolytic (a substance that can selectively induce the death and removal of senescent cells). The experiments discussed in this paper show that Epilobium fleischeri extract can selectively clear senescent cells from the skin. In vitro evidence demonstrates the targeted elimination of senescent fibroblasts by Epilobium fleischeri extract, which is mediated by bioactive flavonoids. In vivo studies have shown the reduced expression of senescence biomarkers, improved collagen production, and dramatic improvements in multiple signs of skin ageing. In clinical trials, elasticity and tonicity were improved by 18% after two months of using a cream with 3% Epilobium fleischeri extract as compared with a control group using a placebo cream. Note de contenu : - Senolytic science — a breakthrough - Senescent zombie cells damage tissue - Key markers of senescence - Epilobium fleischeri extract - The mode of action of Epilobium fleischeri extract - Flavonoids, the source of senolytic activity - Senolytic activity - Visualizing apoptosis in real time - Collagen boosting - Senolytic activity on whole tissue - Clinical study - Sustainability - Fig. 3 : The mode of action of Epilobium Fleischeri dry extract - Fig. 4 : Myricetin and Myricitrin, the 3-0-rhammoside of Myricetin En ligne : https://drive.google.com/file/d/1wzUsAdZFeIfVL0mMbeTeURP98wwsYemT/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=41048 [article]

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