[article]
Titre : |
Protecting telomeres to ensure longevity |
Type de document : |
texte imprimé |
Auteurs : |
David Boudier, Auteur ; L. Quillot, Auteur ; Julie Dorotyn, Auteur ; Laetitia Marchand, Auteur ; Magalie Pinel, Auteur |
Année de publication : |
2013 |
Article en page(s) : |
p. 45-48 |
Note générale : |
Bibliogr. |
Langues : |
Anglais (eng) |
Catégories : |
ADN -- Réparation Antiâge Biomolécules actives Extraits de plantes:Extraits (pharmacie) Peau -- Soins et hygiène TélomèresUn télomère est une région hautement répétitive, donc non codante, d'ADN à l'extrémité d'un chromosome. À chaque fois qu'un chromosome en bâtonnet d'un eucaryote est dupliqué, lors de la réplication, qui précède la mitose (division cellulaire), le complexe enzymatique de l'ADN polymérase s'avère incapable de copier les derniers nucléotides : l'absence de télomère signifierait la perte rapide d'informations génétiques nécessaires au fonctionnement cellulaire.
Les télomères raccourcissent avec l’âge, l’inflammation et le stress. Des études ont montré que des télomères courts sont associés à un risque plus élevé de maladies liées à l’âge.
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Index. décimale : |
668.5 Parfums et cosmétiques |
Résumé : |
Today, it seems that different factors are interlinked and combined with other processes and on different levels to contribute to the skin ageing phenomenon. On a cell level, telomeres’ shortening is considered one of the main characteristics of ageing. Over the course of cell division, the telomeres gradually shorten until they reach a critical minimum size, triggering cell senescence which contributes to the degeneration of the skin tissue and its ageing.
In skin cells, telomeres are stabilised by a multiprotein complex, called telosome or shelterin. In the absence of the telosome, the weakened telomeres shorten more quickly at each division.
Stress (UV, reactive oxygen species, etc.) also accentuates their wear. This leads to gradual depletion of the cells and its premature ageing.
In this article, we discuss the in vitro models we developed for studying the capacity of a natural active ingredient to limit deterioration of the telosome. This active prevents the accelerated erosion of telomeres induce by stress and slows down premature passage of skin cells into the senescent phase and thus ensures longevity.
This new anti-ageing strategy is supported by proven cosmetic benefits : the marks of ageing on the skin are reduced and the perceived age is improved. |
Note de contenu : |
- The telosome : the protective cap of telomeres
- MATERIALS AND METHODS : Procedure of cell culture to investigate the skin ageing process and the effect of Kappaphycus alvarezii extract - Protection of telomeres : expression of telosome moleculres POT1 et TPP1 (in vitro) - Shortening of telomeres (in vitro) - Limiting of the cells entry into senescence (in vitro) - Selected panel and procedure for in vivo studies - Study of wrinkles by fringe projection - Study of perceived age - Statistical analysis
- RESULTS AND DISCUSSION : Protection of telomeres : expression of telosome molecules POT1 and TPP1 (in vitro) - Shortening of telomeres (in vitro) - Limiting of the cells' entry into senescence (in vitro) - Improvement of wrinkles - Improvement of the perceived age |
En ligne : |
https://drive.google.com/file/d/1-glfHupKyYGASvSSkhEwU8-0pMyjg7Fm/view?usp=drive [...] |
Format de la ressource électronique : |
Pdf |
Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=17423 |
in PERSONAL CARE EUROPE > Vol. 6, N° 1 (02/2013) . - p. 45-48
[article]
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