Jade material in vitro and in vivo : A study on the anti-inflammatory and repair efficacy of jade material on the skin / Xiaohong Shu in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 45, N° 2 (03-04/2023)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 45, N° 2 (03-04/2023) . - p. 177-186 Titre : Jade material in vitro and in vivo : A study on the anti-inflammatory and repair efficacy of jade material on the skin Type de document : document électronique Auteurs : Xiaohong Shu, Auteur ; Ling Wang, Auteur ; Ruina Qu, Auteur ; Li Li, Auteur ; Xi Wang, Auteur Année de publication : 2023 Article en page(s) : p. 177-186 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Anti-inflammatoires Dermo-cosmétologie Jade et constituants Peau -- Inflammation Peau -- Physiologie Peau -- Soins et hygiène Tests de sécurité Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : The biological safety of natural jade materials and assembled jade-activated materials on cells and their anti-inflammatory and damage repair functions, as well as the repair function on sensitive skin, were studied utilizing in vitro cell biology and in vivo. - Methods : Human skin fibroblasts were used as model cells to conduct cytotoxicity experiments in vitro, and the effects on the expression of inflammatory factors and growth factor-related genes in fibroblasts were explored. The gene expression values of inflammatory factors IL-1, IL-6, TNF-α and cytokines epidermal growth factors, fibroblast growth factors and COL1A1 in fibroblasts were measured by polymerase chain reaction test. Thirty women with sensitive skin were selected to apply a mask containing jade extract three times a week. After two weeks, non-invasive measures related to skin sensitivity were tested. - Results : We confirmed the presence of anti-inflammatory effects in both jade materials, with the effects of the assembled activated jade material being superior to that of the natural jade material. Jade extracts significantly increased the gene expressions of EGF, FGF and COL1A1 in HDF. The results of the in vivo study showed that the mask containing jade extract could significantly increase the skin hydration and decrease the rate of transepidermal water loss and skin lactic acid sting test scores after two weeks of use. Subjective evaluations confirmed improvements in skin dryness, smoothness and fineness. No new sensitization occurred in subjects, and the product was non-irritating. No adverse skin reactions were observed during the test. - Conclusions : The jade materials were able to downregulate the expression of inflammatory factor genes, up-regulate the expression of growth factor genes, and improve the anti-inflammation and repair ability of skin. Furthermore, the test results of participants with sensitive skin after using the mask containing jade extract showed that the mask has repairing ability. Note de contenu : - MATERIALS AND METHODS : In vitro experiments - Effects of jade materials on gene expression of inflammatory cytokines and growth factors in HDF - Statistical analysis - In vivo experiment - RESULTS : In vitro experimental results and discussion - Anti-inflammatory effects of jade materials - Reparative effects of jade materials on skin wounds - In vivo experimental results - DISCUSSION : In vitro experimental discussion - Table 1 : Primer sequences for qPCR - Table 2 : Lactic acid sting test scores of the skin at different time points DOI : https://doi.org/10.1111/ics.12829 En ligne : https://drive.google.com/file/d/1KvuNE6Cejjs0x77KaXASVgHYHgPNIs55/view?usp=share [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=39168 [article]

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