[article]
| Titre : |
The effect of synthetic acetylhexapeptide-8 (AH8) on sebaceous function |
| Type de document : |
document électronique |
| Auteurs : |
Vivian Y. Shi, Auteur ; Waqas Burney, Auteur ; Anastasia Shakhbazova, Auteur ; Adrianne Pan, Auteur ; Lauren A. Hassoun, Auteur ; Shreya Sharma, Auteur ; Raja K. Sivamani, Auteur |
| Année de publication : |
2022 |
| Article en page(s) : |
p. 477-483 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Acétylhexapeptide-8
Cosmétiques
Dermo-cosmétologie
Peau -- Soins et hygiène
Séborrhée
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
- Objective : This study aims to evaluate the in vitro and clinical effects of topical acetylhexapeptide-8 (AH8) on the appearance of oily skin.
- Method : In vitro SEB-1 human sebocyte cell lines were exposed to different concentrations of AH8, then the lipid content of the sebocytes was measured. For the randomized, controlled, split-face clinical study, participants received AH8 10% lotion formulated in Cetaphil Moisturizing Facial Lotion on one side of their face and the control vehicle lotion on the other side of their face. Facial oiliness was assessed by a trained physician using a three-point grading system, high-resolution digital photographs, and a sebumeter (SM815). Participants also filled out self-assessments of their skin oiliness.
- Results : The in vitro experiments showed that sebocyte lipid content significantly decreased after AH8 treatment (p < 0.05 at 0.00005% AH8, p = 0.09 at 0.0005% AH8, p < 0.05 at 0.005% AH8, and p < 0.001 at 0.025% AH8). In the clinical study, participants trended towards a 10% reduction (p = 0.16) in sebum production after AH8 treatment in comparison to the vehicle treatment.
- Conclusion : AH8 inhibits the accumulation of lipids in sebocytes in vitro without altering cell proliferation or SREBP-1 expression. Topical AH8 trended towards decreased sebum production in human participants. The use of AH8 may serve as a promising agent to reduce sebocyte lipid production and the appearance of oily skin. |
| DOI : |
https://doi.org/10.1111/ics.12795 |
| En ligne : |
https://drive.google.com/file/d/1GaypXzW7f0AA6KAN0yhLqW26sTYf_-rl/view?usp=shari [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38147 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 44, N° 4 (08/2022) . - p. 477-483
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