Effects of watercress extract fraction on R-spondin 1-mediated growth of human hair / Masakazu Hashimoto in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 44, N° 2 (04/2022)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 44, N° 2 (04/2022) . - p. 154-165 Titre : Effects of watercress extract fraction on R-spondin 1-mediated growth of human hair Type de document : document électronique Auteurs : Masakazu Hashimoto, Auteur ; Yuka Kawai, Auteur ; Teruaki Masutani, Auteur ; Kiyotaka Tanaka, Auteur ; Kenichi Ito, Auteur ; Arunasiri Iddamalgoda, Auteur Année de publication : 2022 Article en page(s) : p. 154-165 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Alopécie Cheveux -- Croissance Cheveux -- Soins et hygiène Cheveux gris Cresson et constituants Cuir chevelu -- Soins et hygiène Extraits de plantes:Extraits (pharmacie) Produits capillaires Tests de sécurité Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Hair loss and greying affect men and women of all ages, often causing psychosocial difficulties. Dickkopf-1 (DKK1), a major hair loss factor secreted from dermal papilla (DP) cells in response to the secretion of dihydrotestosterone (DHT), has been reported to induce and accelerate androgenetic alopecia (AGA). In addition, DKK1 acts as a potent suppressor of melanogenesis and is closely related to hair colour. R-spondin 1 (RSPO1) is a secretory agonist of Wnt signalling known to antagonize the effects of DKK1, including DKK1-mediated hair follicle suppression. In this study, we investigated the effect of watercress extract (WCE) on the secretion of RSPO1 and DKK1 from DP cells as well as its anti-hair loss effect in human hair follicles and patients. - Methods : The in vitro secretion of RSPO1 and DKK1 was measured by ELISA. Human hair follicles were collected from the scalp of a female donor and used for ex vivo organ culture to investigate the effects of WCE on human hair loss. Finally, a 6-month human clinical trial was conducted to examine the effect of WCE-containing lotion on hair growth in a male panel. - Results : WCE significantly upregulated RSPO1 secretion and suppressed DKK1 secretion in a dose-dependent manner, even in the presence of DHT. WCE-treated hair follicles elongated 1.6-fold compared with the control, and the level of RSPO1 production in DP as well as RSPO1 bound to the outer root sheath (ORS) increased. In the clinical trial, the hair lotion containing 2% WCE increased hair thickness and density to improve against hair loss symptoms. - Conclusion : WCE exhibited a strong anti-androgenic effect through its ability to suppress DKK1 secretion and antagonize DKK1 via RSPO1. These findings highlighted the potential use of WCE for the treatment of hair loss. Note de contenu : - MATERIALS AND METHODS : Fractionation and identification of WCE components - Treatment with RSPO1, DKK1 and Wnt-3a - Measurements of protein secretion from DP cells - Elongation and immunohistochemistry of hair follicle ex vivo - Statistical analyses - RESULTS : Enhancement of Wnt signalling by RSPO1 - Effect of WCE on RSPO1 and DKK1 secretion in DP cells - Hair follicle elongation ex vivo - Clinical trial DOI : https://doi.org/10.1111/ics.12764 En ligne : https://drive.google.com/file/d/1mEtlNb-0EHtJAaI-UEiACOIUsnbeQepv/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=37719 [article]

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Upcycled active for hair greying prevention / Katharina Kappler in GLOBAL PERSONAL CARE, Vol. 24, N° 4 (04/2023)  

[article]  inGLOBAL PERSONAL CARE > Vol. 24, N° 4 (04/2023) . - p. 51-53 Titre : Upcycled active for hair greying prevention Type de document : texte imprimé Auteurs : Katharina Kappler, Auteur Année de publication : 2023 Article en page(s) : p. 51-53 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Biomolécules actives Cheveux -- Soins et hygiène Cheveux gris Cosmétiques Mandarine et constituants Mélanine Mélanogénèse Produits capillaires Produits et matériaux recyclés Index. décimale : 668.5 Parfums et cosmétiques Résumé : Mibelle Biochemistry explains its anti-hair greying essence that stimulates melanin synthesis and protects melanocytes from stress-induced malfunction. Based on a sustainable upcycling process of a unique locally sourced mandarin from the Greek island of Chios, MelanoGrayâ„¢ is an anti-hair greying essence that stimulates melanin synthesis and protects melanocytes from stress-induced malfunction. This unique active ingredient was shown to markedly reduce the quantity of grey hair in both men and women, even during times of psychoemotional stress when hair greying can be accelerated. Note de contenu : - Hair greying - Melanogenesis - the production of hair pigments - Anti-greying cosmetic active upcycled from aromatic waste - Stimulation of melanogenesis - Protection against stress-induced malfunction of melanocytes - Anti-greying effect - Fig. 1 : Melanin synthesis En ligne : https://drive.google.com/file/d/10W_bRVsXUZgsFaBJwsyXkAHsAb5q0oTN/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=39410 [article]

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