Dermohacking senescence with a lab-grown active / Clara Vigo in GLOBAL PERSONAL CARE, Vol. 24, N° 4 (04/2023)  

[article]  inGLOBAL PERSONAL CARE > Vol. 24, N° 4 (04/2023) . - p. 106-108 Titre : Dermohacking senescence with a lab-grown active Type de document : texte imprimé Auteurs : Clara Vigo, Auteur ; Elizabeth Escudero, Auteur ; David Manzano, Auteur Année de publication : 2023 Article en page(s) : p. 106-108 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge Biomolécules actives Dermo-cosmétologie Peau -- Soins et hygiène Sénolyse Index. décimale : 668.5 Parfums et cosmétiques Résumé : Beauty consumers are paying more attention to ingredients than ever before. As value creation becomes a defining feature of the healthcare industry in general, innovative technologies bring lab-grown ingredients to a new level for the everyday more health-eager mature consumer. Arising from this surge of innovative cosmetics, preventative healthcare, and the latest unprecedented scientific advances in cell senescence, Provital is aking the lead in a new type of cosmetics that will push the boundaries on efficacy and sustainability in cosmetic ingredients: Dermohacking cosmetics. Provital presents Altheostemâ„¢ as its first ‘dermohacker’, an Althaea rosea (hollyhock) flower stem cell active that has proven its ability to selectively eliminate skin cellular senescence. This senolytic, vegan-compliant, COSMOSapproved active of 100% natural origin (ISO16128) also proved its significant well-aging activity on the volunteers in an innovative in vivo study based on instrumental and artificial intelligence tools. Note de contenu : - A lab-grown ingredient : Althaea rosea petal stem cells - An innovative mechanism of action: in vitro-proven senolytic activity - Quantifying the well-aging power with artificial intelligence En ligne : https://drive.google.com/file/d/1GWyooKnvZ83FfuF0kJYD90fLnJ-140je/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=39420 [article]

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Dermohacking senescence with a new aI-proven & biotech ingredient / Clara Vigo Xanco in SOFW JOURNAL, Vol. 149, N° 9 (09/2023)  

[article]  inSOFW JOURNAL > Vol. 149, N° 9 (09/2023) . - p. 2-8 Titre : Dermohacking senescence with a new aI-proven & biotech ingredient Type de document : texte imprimé Auteurs : Clara Vigo Xanco, Auteur ; Siham Bouhrir, Auteur ; Elizabeth Escudero, Auteur ; David Manzano, Auteur Année de publication : 2023 Article en page(s) : p. 2-8 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge Bien-être Biotechnologie Cellules souches végétales Cosmétiques Dermo-cosmétologie Développement durable Intelligence artificielle Peau -- Soins et hygiène Sénolyse Vieillissement Vieillissement cutané -- Prévention Index. décimale : 668.5 Parfums et cosmétiques Résumé : Modern science has opened a variety of new ways to improve survival and quality of life. Meanwhile, the recent movement towards preventative health among the ever-increasing mature segment of the population, has boosted the emerged success of new healthcare concepts such as biohacking. This one-health movement goes hand in hand with unprecedented scientific advances appearing in the anti-aging field, particularly for cellular senescence. As these new advances on cellular senescence take ground in the scientific community, the beauty industry can better tap into the opportunities that this longevity era can offer. In this regard, Provital is taking the lead in a new type of cosmetics that will leverage technology, science, natural and holistic preferences to push the boundaries on efficacy and selectivity, while still supporting an environmentally friendly brand positioning: Dermohacking cosmetics. Altheostemâ„¢ is Provital’s first dermohacker. An Althaea rosea stem cell active that has proven its ability to selectively eliminate cellular senescence. This lab-grown active ingredient leverages biotechnology for a selective biological action on aged skin. In this article, Provital describes how the positive effects of its senolytic activity are thoroughly tested in vitro and in vivo, using both instrumental and Artificial Intelligence analysis, thus unveiling its well-aging power. Note de contenu : - Welcome to dermohacking cosmetifs - Sustainable lab-grown ingredient : Althaea rosea petal stem cells - Selective mechanism of action : Leading-edge senolytic activity - Quantifiable well-aging powder : Clinical study strenthened by artificial intelligence : Clinical methods - Clinical results & discussion - Dermohacking senescence through the eternal power of plant stem cells En ligne : https://drive.google.com/file/d/163Rlh8HlKch2Eou6mHJ1SPu2B4uADWeQ/view?usp=share [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=39948 [article]

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A novel strategy for holistic skin rejuvenation / Julia Baumann in SOFW JOURNAL, Vol. 148, N° 10 (10/2022)  

[article]  inSOFW JOURNAL > Vol. 148, N° 10 (10/2022) . - p. 28-32 Titre : A novel strategy for holistic skin rejuvenation Type de document : texte imprimé Auteurs : Julia Baumann, Auteur ; Franziska Wandrey, Auteur ; Fred Zülli, Auteur Année de publication : 2022 Article en page(s) : p. 28-32 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge Biomolécules actives Cellules souches Dermo-cosmétologie Extraits de plantes:Extraits (pharmacie) Peau -- Soins et hygiène Rhododendron ferrugineum et constituants Sénolyse Index. décimale : 668.5 Parfums et cosmétiques Résumé : A revolutionary anti-aging concept, senolytics, has entered the medical world. Demonstrating remarkable results in early trials, senolytics can provoke rejuvenation in various tissues by specifically eliminating senescent cells without harming healthy cells. This concept has now been adapted for the cosmetic industry, by targeting and eliminating senescent fibroblasts in aged and photo-aged skin. To optimally complete skin rejuvenation however, the eliminated fibroblasts must be replaced with new cells - a feat that can be achieved by the activation of dermal stem cells. This revolutionary idea has been realized with the innovative ingredient concept SenoCellTecTM. Note de contenu : - MATERIALS AND METHODS : Senolytic assay - Dermal - epidermal communication in a full thickness skin model - Clinical study : effects of alipine rose leaf extract on skin redness - RESULTS AND DISUSSION : A novel senolytic active from Swiss alpine rose leaves - Holistic rejuvenation treatment : activating dermal progenitor cells - Clinically proven efficacy of the natural plant extracts En ligne : https://drive.google.com/file/d/1tRfffLTR5L7eo7o6V1MzjxLg8xAvRBar/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38246 [article]

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Senolytic science : plant extract for well-ageing / Leithe Budel in GLOBAL PERSONAL CARE, Vol. 25, N° 4 (04/2024)  

[article]  inGLOBAL PERSONAL CARE > Vol. 25, N° 4 (04/2024) . - p. 117-123 Titre : Senolytic science : plant extract for well-ageing Type de document : texte imprimé Auteurs : Leithe Budel, Auteur ; François Paul, Auteur Année de publication : 2024 Article en page(s) : p. 117-123 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge Cosmétiques Dermo-cosmétologie Epilobium fleischeri Extraits de plantes:Extraits (pharmacie) Peau -- Soins et hygiène Sénolyse Index. décimale : 668.5 Parfums et cosmétiques Résumé : DSM-Firmenich reveals the findings of research that shows how a Epilobium fleischeri extract can selectively clear senescent cells – so-called 'zombie' cells - from the skin. Senescence cells are seen as fundamental drivers of tissue ageing. Senescent 'zombie cells' accumulate with age and cause damage through damaging secretions. Eliminating these cells is a revolutionary approach to restoring youthful skin. Research by experts in ageing has revealed that Epilobium fleischeri extract is a natural botanical senolytic (a substance that can selectively induce the death and removal of senescent cells). The experiments discussed in this paper show that Epilobium fleischeri extract can selectively clear senescent cells from the skin. In vitro evidence demonstrates the targeted elimination of senescent fibroblasts by Epilobium fleischeri extract, which is mediated by bioactive flavonoids. In vivo studies have shown the reduced expression of senescence biomarkers, improved collagen production, and dramatic improvements in multiple signs of skin ageing. In clinical trials, elasticity and tonicity were improved by 18% after two months of using a cream with 3% Epilobium fleischeri extract as compared with a control group using a placebo cream. Note de contenu : - Senolytic science — a breakthrough - Senescent zombie cells damage tissue - Key markers of senescence - Epilobium fleischeri extract - The mode of action of Epilobium fleischeri extract - Flavonoids, the source of senolytic activity - Senolytic activity - Visualizing apoptosis in real time - Collagen boosting - Senolytic activity on whole tissue - Clinical study - Sustainability - Fig. 3 : The mode of action of Epilobium Fleischeri dry extract - Fig. 4 : Myricetin and Myricitrin, the 3-0-rhammoside of Myricetin En ligne : https://drive.google.com/file/d/1wzUsAdZFeIfVL0mMbeTeURP98wwsYemT/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=41048 [article]

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Senolytics : Eliminating senescent cells / Julia Baumann in GLOBAL PERSONAL CARE, Vol. 23, N° 1 (01/2022)  

[article]  inGLOBAL PERSONAL CARE > Vol. 23, N° 1 (01/2022) . - p. 35-37 Titre : Senolytics : Eliminating senescent cells Type de document : texte imprimé Auteurs : Julia Baumann, Auteur ; Franziska Wandrey, Auteur ; Fred Zülli, Auteur Année de publication : 2022 Article en page(s) : p. 35-37 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Anti-inflammatoires Cuir chevelu -- Soins et hygiène Dermo-cosmétologie Extraits de plantes:Extraits (pharmacie) Sénolyse Index. décimale : 668.5 Parfums et cosmétiques Résumé : Cellular senescence, a condition of irreversible cell cycle arrest, can lead to inflammation and accelerated ageing of tissues, including the skin. To prevent this, current strategies aim specifically to eliminate the senescent cells, or ‘zombie cells’, by means of senolytics. Sensitive scalps are a prominent problem and one potential treatment option is the use of senolytics in scalp care. As with the skin, zombie cells in the scalp can cause local inflammation, leading to dry and irritated scalps, so clearing these cells could promote a healthy scalp. An extract from the leaves of the Swiss Alpine rose was found to have strong senolytic activity in fibroblasts. In a placebo-controlled clinical study, the extract further demonstrated a significant soothing effect on sensitive scalps. This study firstly highlights the positive impact of senolytics in scalp health and care. Note de contenu : - Nature' senolytic - Sensitive scalps : A common problem - Methods - Results a discussion - Scalp redness & itching En ligne : https://drive.google.com/file/d/1Fc4-mpR4S9dqy4i40gj4q0-vwYFPEzU_/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=37087 [article]

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