| Titre : |
Processing of biodegradable polymer composites as a drug delivery system in vitro |
| Type de document : |
texte imprimé |
| Auteurs : |
S.-J. Liu, Auteur ; C.-H. Tsai, Auteur ; S.-S. Lin, Auteur ; S. W.-N. Ueng, Auteur |
| Année de publication : |
1999 |
| Article en page(s) : |
p. 322-325 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Index. décimale : |
668.9 Polymères |
| Résumé : |
Biomedical engineering - This report explores the alternative of processing biodegradable polymer-antibiotic composites as a long-term drug release. Polymer-antibiotic composite beads were manufactured by a compression-sintering technique. An elution method was employed to characterize the release rate of antibiotic over a 35-day period at 37°C. Biodegradable polymer composites released high concentrations of antibiotic (well above the breakpoint sensitivity concentration) in vitro for the period of time needed to treat bone infection; i.e. 4 to 6 weeks. By changing the processing variables, one is able to control the release rate of the beads. This provides advantages of meeting the specific antibiotic requirement for patients with various surgical infections. |
| DOI : |
10.3139/217.1557 |
| En ligne : |
https://drive.google.com/file/d/16KeCweKZhhX_kBE1_lRlHUf4ZiUhHTsu/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=16119 |
in INTERNATIONAL POLYMER PROCESSING > Vol. XIV, N° 4 (12/1999) . - p. 322-325
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Processing of biodegradable polymer composites as a drug delivery system in vitro in INTERNATIONAL POLYMER PROCESSING, Vol. XIV, N° 4 (12/1999)
