Characteristics of healthy and androgenetic alopecia scalp microbiome: Effect of Lindera strychnifolia roots extract as a natural solution for its modulation / Edith Filaire in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 42, N° 6 (12/2020)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 42, N° 6 (12/2020) . - p. 615-621 Titre : Characteristics of healthy and androgenetic alopecia scalp microbiome: Effect of Lindera strychnifolia roots extract as a natural solution for its modulation Type de document : document électronique Auteurs : Edith Filaire, Auteur ; A. Dreux, Auteur ; Carine Boutot, Auteur ; Edwige Ranouille, Auteur ; Jean-Yves Berthon, Auteur Année de publication : 2020 Article en page(s) : p. 615-621 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Alopécie Cheveux -- Soins et hygiène Cuir chevelu -- Soins et hygiène Extraits de plantes:Extraits (pharmacie) Malassezia Microbiologie Microbiote Produits capillaires Staphylococcus epidermis Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : The human scalp harbours a vast community of microbiotal mutualists. Androgenetic alopecia (AGA), the most common form of hair loss in males, is a multifactorial condition involving genetic predisposition and hormonal changes. The role of microflora during hair loss remains to be understood. After having characterized the scalp microbiota of 12 healthy male subjects and 12 AGA male subjects (D0), the aim of this investigation was to evaluate the capacity of Lindera strychnifolia root extract (LsR) to restore a healthy bacterial and fungal scalp microflora after 83 days (D83) of treatment. - Material and methods : The strategy used was based on high-throughput DNA sequencing targeting the encoding 16S ribosomal RNA for bacteria and Internal Transcribed Spacer 1 ribosomal DNA for fungi. - Results : Test analysis of relative abundance comparing healthy and AGA subjects showed a significant increase of Cutibacterim acnes (P < 0.05) and Stenotrophomonas geniculata (P < 0.01) in AGA subjects. AGA scalp condition was also associated with a significant (P < 0.05) decrease of Staphylococcus epidermidis relative abundance. A lower proportion of Malassezia genus in samples corresponding to AGA scalps and an increase of other bacterial genera (Wallemia, Eurotium) were also noted. At the species level, mean relative abundance of Malassezia restricta and Malassezia globosa were significantly lower (P < 0.05) in the AGA group. Eighty-three days of treatment induced a significant decrease in the relative abundance of C. acnes (P < 0.05) and S. geniculata (P < 0.01). S. epidermidis increased significantly (P < 0.05). At the same time, LsR treatment induced a significant increase in the proportion of M. restricta and M. globosa (P < 0.05). - Conclusion : Data from sequencing profiling of the scalp microbiota strongly support a different microbial composition of scalp between control and AGA populations. Findings suggest that LsR extract may be a potential remedy for scalp microbiota re-equilibrium. Note de contenu : - MATERIALS AND METHODS : Preparation of extract - Subject recruitment - Treatment - Swab sample collection - DNA extraction - Amplification and sequencing of 16S RNA gene - Amplification and sequencing of ITS1 RNA gene - Statistical analysis - RESULTS : Identification of bacteria communities: Taxonomic abundance analysis - Identification of fungal communities - Effect of LsR extract treatment on microbiome - Table 1 : Mean relative abundance at the phylum, genus and species level at D0 (beginning of the study) for healthy and AGA group and after the LsR treatment for AGA group (D83) - Table 2 : Mean relative abundance at the phylum and genus level at D0 (beginning of the study) for healthy and AGA group, and after the LsR treatment for AGA group (D83) - Table 3 : Relative abundance at the species belonging to Malassezia species at D0 (beginning of the study) for healthy and AGA group and after the LsR treatment for AGA group (D83) DOI : https://doi.org/10.1111/ics.12657 En ligne : https://drive.google.com/file/d/1Q-DKEKbXzs_kXntEba2nTpj1xMHrkRdX/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35428 [article]

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