Mechanical epilation exerts complex biological effects on human hair follicles and perifollicular skin: An ex vivo study approach / Marta Bertolini in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 46, N° 2 (04/2024)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 46, N° 2 (04/2024) . - p. 175-198 Titre : Mechanical epilation exerts complex biological effects on human hair follicles and perifollicular skin: An ex vivo study approach Type de document : texte imprimé Auteurs : Marta Bertolini, Auteur ; Jennifer Gherardini, Auteur ; Jérémy Chéret, Auteur ; Majid Alam, Auteur ; Mathias Sulk, Auteur ; Natalia V. Botchkareva, Auteur ; Tamas Biro, Auteur ; Wolfgang Funk, Auteur ; Frieder Grieshaber, Auteur ; Ralf Paus, Auteur Année de publication : 2024 Article en page(s) : p. 175-198 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Cheveux -- Croissance Cuir chevelu Epilage Evaluation Inflammation Peau -- analyse Tests de sécurité Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Electrical epilation of unwanted hair is a widely used hair removal method, but it is largely unknown how this affects the biology of human hair follicles (HF) and perifollicular skin. Here, we have begun to explore how mechanical epilation changes selected key biological read-out parameters ex vivo within and around the pilosebaceous unit. - Methods : Human full-thickness scalp skin samples were epilated ex vivo using an electro-mechanical device, organ-cultured for up to 6 days in serum-free, supplemented medium, and assessed at different time points by quantitative (immuno-)histomorphometry for selected relevant read-out parameters in epilated and sham-epilated control samples. - Results : Epilation removed most of the hair shafts, often together with fragments of the outer and inner root sheath and hair matrix. This was associated with persistent focal thinning of the HF basal membrane, decreased melanin content of the residual HF epithelium, and increased HF keratinocyte apoptosis, including in the bulge, yet without affecting the number of cytokeratin 15+ HF epithelial stem cells. Sebocyte apoptosis in the peripheral zone was increased, albeit without visibly altering sebum production. Epilation transiently perturbed HF immune privilege, and increased the expression of ICAM-1 in the bulge and bulb mesenchyme, and the number of perifollicular MHC class II+ cells as well as mast cells around the distal epithelium and promoted mast cell degranulation around the suprabulbar and bulbar area. Moreover, compared to controls, several key players of neurogenic skin inflammation, itch, and/or thermosensation (TRPV1, TRPA1, NGF, and NKR1) were differentially expressed in post-epilation skin. - Conclusion : These data generated in denervated, organ-cultured human scalp skin demonstrate that epilation-induced mechanical HF trauma elicits surprisingly complex biological responses. These may contribute to the delayed re-growth of thinner and lighter hair shafts post-epilation and temporary post-epilation discomfort. Our findings also provide pointers regarding the development of topically applicable agents that minimize undesirable sequelae of epilation. Note de contenu : - MATERIALS AND METHODS : Human samples - Human skin organ culture and ex vivo epilation - Ex vivo assessment of epilation - Histochemistry - Immunohistochemistry and immunofluorescence microscopy - Microscopy and quantitative (immuno-)histomorphometry - Statistical analysis - RESULTS : Epilation ex vivo removes almost the entire hair shaft and induces morphological changes in the HF epithelium - Epilation reduces follicular melanin content and melanogenesis ex vivo - Epilation selectively promotes apoptosis in hair matrix and bulge epithelium but does not compromise the epithelial stem cell pool ex vivo - Epilation induces sebocyte apoptosis but does not appear to alter sebum production - Epilation ex vivo transiently perturbs HF immune privilege - Epilation induces perifollicular inflammation ex vivo - Epilation causes transient changes in the expression of key components of neurogenic skin inflammation, thermoregulation, itch, and/or pain in HFs ex vivo DOI : https://doi.org/10.1111/ics.12923 En ligne : https://drive.google.com/file/d/1U7feLvo9Dv8VxiJ9cipcR_p0N6MbplFC/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=40906 [article]

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A new peptide mimicking a good sleep in times of pandemia / Miriam Mateu in SOFW JOURNAL, Vol. 146, N° 12 (12/2020)  

[article]  inSOFW JOURNAL > Vol. 146, N° 12 (12/2020) . - p. 14-19 Titre : A new peptide mimicking a good sleep in times of pandemia Type de document : texte imprimé Auteurs : Miriam Mateu, Auteur ; Patricia Carulla, Auteur ; Marco J. Klein, Auteur ; Ariadna Grau-Campistany, Auteur ; Silvia Pastor, Auteur ; Meritxell Llinas, Auteur Année de publication : 2020 Article en page(s) : p. 14-19 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Glycation Inflammation Interleukines Les interleukines (IL) sont un groupe de cytokines, ainsi nommées car les premières observations semblaient montrer qu'elles étaient exprimées par les globules blancs (leucocytes, d'où -leukin) en guise de moyen de communication (d'où inter-). Les interleukines sont produites par une large variété de tissus et cellules, et que, bien que regroupées sous cette terminologie par commodité, elles ne présentent aucune parenté biochimique ni de fonction entre elles. Elles ont été classées par numéro au gré des découvertes. Au début 2006, 31 cytokines sont connues et dénommées sous l'intitulé IL. La fonction du système immunitaire dépend en grande partie des interleukines et de rares déficiences de certaines d'entre elles ont été décrites, conduisant à des maladies auto-immunes ou des immunodéficiences. Mélatonine Peptides Sommeil Index. décimale : 668.5 Parfums et cosmétiques Résumé : Regularly skipping sleep is associated with chronic low inflammation, oxidative stress and weakened immune system. These three factors are interconnected and all of them generate further inflammation, oxidative stress and worsen the immune system. The alarmin interleukin IL-33 is a pro-inflammatory cytokine released upon cell damage activating the immune response and inducing oxidative stress and further inflammation. IL-33 is over-expressed in conditions of chronic inflammation like a topic dermatitis and obstructive sleep apnea. Sleep disturbance also presents high levels of glucose which may glycate proteins of the skin and the endothelial and lymphatic vessels, weakening their integrity and producing oxidative stress and more inflammation. In addition, melatonin levels are decreased, which not only affects its circadian role but also as a potent antioxidant and antiglycant. iPeptideâ„¢ is a peptide that was discovered to down-regulate IL-33 expression through a Big Data analysis. It showed to modulate chronic inflammation and damages induced by hyperglycemia due to sleep deprivation. It also presented a melatonin-like protection effect and reinforced the first line of immune defense. In vivo, it decreased fatigue features, awakened sleepy lookand had a local cool effect. Note de contenu : - MATERIALS AND METHODS : Gene expression modulation of sleep deprivation – Modulation of IL-33 release – Regulating hyperpigmentation – De-stressing capillarity – Reinforcing lymphatic integrity – Melatonin-like protection against glycation and lipid peroxidatione – Melatonin-like modulation of the epidermal immune protection – Guarding from hyperglycemia damage – Anti-fatigue efficacy in sleep deprived volunteers – Refreshing effect in sleep deprived volunteers - RESULTS AND DISCUSSION : Gene expression modulation of sleep deprivation – Modulation of IL-33 release – Regulating hyperpigmentation – De-stressing capillarity – Reinforcing lymphatic integrity – Melatonin-like protection against glycation and lipid peroxidation – Melatonin-like modulation of the epidermal immune protection – Guarding from hyperglycemia damage – Anti-fatigue efficacy in sleep deprived volunteers – Refreshing effect in sleep deprived volunteers - Fig. 1 : Melatonin-like protection of the peptide against glycationand lipid peroxidation - Fig. 2 : Protection against glycation of human skin explants treated with MGO and non-treated and treated with 0.005 mg/mL ofpeptide. Fibrillin-1 in green - Fig. 3 : Increase of the angle of the eye opening (+21%) in a 59-year-old volunteer before applying a cream with 0.015 mg/m/ of peptide and after 28 days - Fig. 4 : Fatigue features improvement, which is the average of tiredness, dark circles, eyebags and wrinkles - Fig. 5 : Local cooling effect (-0.7°C) in a volunteer of 35 years old before applying a cream with 0.015 mg/mL of peptide and after 28 days - Fig. 6 : Dark circles improvement in a 37-year-old volunteer applying a cream with 0.015 mg/mL of peptide and after one week En ligne : https://drive.google.com/file/d/1mOAQywzRfktLYNaWWiMLmZWyVYXfSm75/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35002 [article]

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