[article]
| Titre : |
Histamine-induced melanogenesis : biochemical evidence and application of "Kakyoku (Pyracantha fortuneana) extract" to undue pigmentation |
| Type de document : |
texte imprimé |
| Auteurs : |
Y. Takahaski, Auteur ; M. Yoshida, Auteur ; T. Shinomiya, Auteur ; S. Inoue, Auteur |
| Année de publication : |
2000 |
| Article en page(s) : |
p. 24-28 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Undue skin pigmentation frequently accompanies chronic or acute inflammation. Several inflammatory mediators have been examined for their ability to stimulate melanin synthesis in human melanocytes. Although histamine is ubiquitous as an inflammatory factor, its involvement in pigmentation remains obscure. We found that histamine induces melanin synthesis via H2 receptors on cultured human melanocytes. When histamine was added to human melanocytes, cell configuration was changed markedly associated with significant increase in tyrosinase activity and melanin contents. These stimulatory effects of histamine were suppressed by an H2 receptor antagonist, but not by for an H1 or H3 antagonist. Furtheremore, an H2 agonist induced morphological changes and increase in tyrosinase activity in human melanocytes. These findings suggested that histamine plays a physiological role in pigmentation because undue skin pigmentation induced by UV exposure, the prolonged process of wound healing, or continuous physical stimuli, was frequently associated with a concomitant increase in tissue histamine levels.
Based on this in vitro evidence, here we also report the development of a new anti-stain cosmetic ingredient with antiallergic action which suppresses generation of histamine. In a screening, we found that an extract from "Kakyoku (Pyracantha fortuneana)", a Chinese plant, has a potent inhibitory activity against the histamine release from mast cells. It also had inhibitory effects on tyrosinase and superoxide anion production in a xanthine oxidase system. In topical application of Kakyoku extract to skin, the improvement of UVB-induced skin pigmentation was observed for 14 out of 20 healthy volunteers. In this study, histamine released by skin stimulation was shown to activate melanocytes, and possibly to induce undue skin pigmentation. In view of these findings, we developed a new ingredient for anti-stain cosmetics, Kakyoku extract, which alleviated UVB-induced skin pigmentation. |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10843 |
in IFSCC MAGAZINE > Vol. 3, N° 1 (01-02-03/2000) . - p. 24-28
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