[article]
| Titre : |
Retinoids : is there a new approach ? |
| Type de document : |
texte imprimé |
| Auteurs : |
Christos C. Zouboulis, Auteur |
| Année de publication : |
2000 |
| Article en page(s) : |
p. 9-17 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Peau -- Soins et hygiène
Rétinoïdes
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Retinoids include nowadays both naturally occurring molecules and synthetic compounds showing specific biological activities resembling those of vitamin A. They affect cell growth and differentiation as well as the synthetic activity of specialized cells (e.g. sebum and collagen synthesis) and possess immunomodulatory and anti-inflammatory properties. Retinoids are supposed to exhibit their activity by regulating the transcription of genes bearing retinoid-responsive elements in their promoter region. This interaction occurs with retinoids bound to the nuclear receptor proteins RARs and RXRs. The expression of retinoid receptors is tissue specific ; skin mainly expresses RARγ and RXRα. Systemic retinoids are currently used in the treatment of several diseases, including severe inflammatory acne, sebaceous hyperplasia and seborrhea (isotretinoin). Topical retinoids are rapidly developing being applied to treat or prevent acne, aging, photodamage, psoriasis, precanceroses, skin cancer and disorders of skin pigmentation (e.g. tretinoin, isotretinoin, retinaldehyde, retinoyl glucoronide, alitretinoin, motretinide, adapalene, tazarotene). They are also included in cosmetic preparations (e.g. retinyl esters, vitamin A). Chronic topical application of retinoids reprograms some aspects of human epidermal differentiation in vivo. The major adverse effect of retinoids is tetragenicity making contraception essential during systemic retinoid treatment in women of child-bearing age. Current retinoid research targets the identification of genes regulated by retinoids, the development of receptor-selective retinoids for tailoring and/or improving their therapeutic profile, the elucidation of the mode of action of compounds which exhibit low binding affinity for retinoids receptors, and the understanding of the physiological activity of new families of retinoids, such as the neutral antagonists and the inverse agonists. |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10803 |
in IFSCC MAGAZINE > Vol. 3, N° 3 (07-08-09/2000) . - p. 9-17
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