| Titre : |
A proof-of-principle study comparing barrier function and cell morphology in face and body skin |
| Type de document : |
texte imprimé |
| Auteurs : |
Mihaela Gorcea, Auteur ; Majella E. Lane, Auteur ; David J. Moore, Auteur |
| Année de publication : |
2019 |
| Article en page(s) : |
p. 613-616 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Avant-bras
Barrière cutanée
Cornéocytes
Couche cornée
Joues
Mesure
Perte insensible en eau
Tailles des cellules
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
- Objective : The purpose of this pilot in vivo study was to investigate corneocyte size and transepidermal water loss (TEWL) in facial cheek and volar forearm skin as a function of consecutive tape stripping. Changes in corneocyte size and transepidermal water loss (TEWL) were measured as a function of stratum corneum (SC) depth at both anatomical sites. To our knowledge, this is the first published quantitative comparison based on these parameters. This work complements our previously published studies on face skin barrier recovery at 24 h and 4 weeks post-tape stripping [Gorcea et al., Skin Res. Technol., 19, 2013, e375-e382 ; Gorcea et al., Int. J. Cosmet. Sci. 35, 2013, 250].
- Methods : Transepidermal water loss in vivo measurements of forearm and facial skin sites were taken before tape stripping commenced (baseline) and after each tape was collected. Optical microscopy and image analysis techniques were employed to characterize corneocyte size as a function of skin depth (tape strip number) for both anatomical sites.
- Results : Transepidermal water loss increased significantly from baseline with sequential tape stripping at both anatomical skin sites. Volar forearm skin required approximately three times as many tapes to 'damage' the SC barrier (arbitrarily defined as twice baseline TEWL) compared to facial cheek skin demonstrating significant differences in barrier properties between cheeks and forearms (P < 0.05). Corneocyte size decreased significantly with depth for both sites (P < 0.001). Corneocytes from face skin were significantly smaller than corneocytes from volar forearm skin.
- Conclusion : Statistically significant differences between facial and body skin stratum corneum cell morphology and transepidermal water loss were demonstrated and quantitatively measured as a function of tape stripping. |
| Note de contenu : |
- METHODS : Volunteer recruitment - Tape stripping - Transepidermal water loss - Corneocyte surface area- Statistical analysis
- RESULTS AND DISCUSSIONS : TEWL : cheeks and volar forearms - Corneocyte size depth profile : facial cheeks and volar forearms - Corneocyte morphology |
| DOI : |
10.1111/ics.12568 |
| En ligne : |
https://drive.google.com/file/d/1aySIeFJSPOBSyMkGUgAKHAdKfgsAqysC/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=33670 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 41, N° 6 (12/2019) . - p. 613-616
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