Basement membrane damage, a sign of early aginig, and laminin 5, a key player in basement membrane care / Satoshi Amano in IFSCC MAGAZINE, Vol. 3, N° 4 (10-11-12/2000)

[article]  inIFSCC MAGAZINE > Vol. 3, N° 4 (10-11-12/2000) . - p. 15-23 Titre : Basement membrane damage, a sign of early aginig, and laminin 5, a key player in basement membrane care Type de document : texte imprimé Auteurs : Satoshi Amano, Auteur ; Yukiko Matsunaga, Auteur ; Nobuko Akutsu, Auteur ; Kuniko Kadoya, Auteur ; Minoru Fukuda, Auteur ; Izumi Horii, Auteur ; Tasuku Takamatsu, Auteur ; Eijiro Adachi, Auteur ; Toshio Nishiyama, Auteur Année de publication : 2000 Article en page(s) : p. 15-23 Note générale : Bibliogr. Langues : Anglais (eng) Index. décimale : 668.5 Parfums et cosmétiques Résumé : Basement membrane (BM) at the dermalepidermal (D-E) junction plays important roles in maintaining the structure and function of skin. However, little is known about the ultrastructural histology and morphology of BM in young skin. We have found that BM structure even in 30-year-old female skin was alterde and showed disruption and reduplication, while such alternations were scarcely present in skin from subjects in the early 20s. This is consistent with the known changes in skin surface texture in the late 20s and early 30s. Such damage and alteration are thought to be a foremost sign of early aging of skin, since altered BM structure, which may be a result of accumulation of repeated damage during normal daily life, is frequently found in aged people. Therefore, early care of the BM is important to prevent skin aging. BM has a complex anchoring structure involving many components, among which laminin 5 is a key component. Laminin 5 has bifunctional domains which can bind integrins of basal keratinocytes and type VII collagen, forming anchoring fibrils. We found that purified laminin 5 accelerated the formation of BM at the D-E junction in a skin-equivalent model. Furthermore, we found that soybean lysophospholipids stimulate laminin 5 production by human cultured keratinocytes, by using a novel laminin 5-specific sandwich ELISA method. An increase of laminin 5 mRNA levels was also confirmed by the TaqMan PCR method. In the lysophospholipid-treated skin-equivalent model, increased deposition of laminin 5 and type IV collagen and more continuous BM were observed at the D-E junction. These results suggest that increased laminin 5 production in epidermal cells enhances the repair of damaged BM at the D-E junction of skin, and this may be an effective approach to prevent skin aging. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10791 [article]

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A Mixture of Magnesium and Calcium Salts Accelerates Skin Barrier Recovery and Improves Surfactant-Induced Dry Skin / M. Denda in IFSCC MAGAZINE, Vol. 5, N° 2 (04-05-06/2002)

[article]  inIFSCC MAGAZINE > Vol. 5, N° 2 (04-05-06/2002) . - p. 107-110 Titre : A Mixture of Magnesium and Calcium Salts Accelerates Skin Barrier Recovery and Improves Surfactant-Induced Dry Skin Type de document : texte imprimé Auteurs : M. Denda, Auteur ; Izumi Horii, Auteur ; Tasuku Takamatsu, Auteur Année de publication : 2002 Article en page(s) : p. 107-110 Note générale : Bibliogr. Langues : Anglais (eng) Tags : 'Stratum  corneum'  Epidermis  Keratinocyte  'PH'  Potassium  Sodium Index. décimale : 668.5 Parfums et cosmétiques Résumé : Ions such as magnesium and calcium play an important role in various biological functions. In the present study, we first visualized the distribution of calcium, potassium, sodium, and hydrogen ions in the human epidermis and examined the effects of skin barrier disruption. In normal skin, both calcium and magnesium were localized at a high concentration in the epidermal granular layer. The hydrogen ion was also high in the upper epidermis. Sodium did not show any obvious gradient over the epidermis. The potassium concentration was the lowest in the upper epidermis. After barrier disruption by tape stripping, the gradients of calcium, magnesium, ant potassium disapeared while the pH gradient was not altered. Topical application of an aqueous solution of magnesium chloride accelerated the barrier recovery after tape stripping. Topical application of magnesium chloride and calcium chloride was found to hasten the barrier recovery more effectively than a solution of magnesium chloride. The mixture of magnesium and calcium chloride improve the conditions for dry, scaly skin induced by sodium dodecyl sulfate. These results suggest that both magnesium and calcium play an important role in the skin barrier homeostasis and that these ions are effective in improving skin condition. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10653 [article]

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