Polyelectrolytes fabrication on magnesium alloy surface by layer-by-layer assembly technique with antiplatelet adhesion and antibacterial activities / Mengke Peng in JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH, Vol. 16, N° 3 (05/2019)  

[article]  inJOURNAL OF COATINGS TECHNOLOGY AND RESEARCH > Vol. 16, N° 3 (05/2019) . - p. 857-868 Titre : Polyelectrolytes fabrication on magnesium alloy surface by layer-by-layer assembly technique with antiplatelet adhesion and antibacterial activities Type de document : texte imprimé Auteurs : Mengke Peng, Auteur ; Xiaodan Zhang, Auteur ; Xiao Xiao, Auteur ; Mengjin Dong, Auteur ; Guowei Zhao, Auteur ; Peng Liu, Auteur ; Yashao Chen, Auteur ; Changhao Wang, Auteur Année de publication : 2019 Article en page(s) : p. 857-868 Note générale : Bibliogr. Langues : Américain (ame) Catégories : Adhésion antiplaquettaire Antibactériens Anticorrosifs Anticorrosion Caractérisation Lysozyme Le lysozyme est une protéine globulaire formée de 129 acides aminés (chez l'être humain), que l'on rencontre dans un certain nombre de sécrétions (larmes, salive, lait maternel, mucus...) et dans le blanc d'Å“uf, chez de nombreuses espèces d'animaux, dont insectes et acariens1. Il s'agit d'une hydrolase acide (EC 3.2.1.17) sécrétée par les granulocytes et les monocytes. Elle détruit la paroi bactérienne en catalysant l'hydrolyse des peptidoglycanes la constituant. Magnésium -- Alliages Polyélectrolytes Polyéthylèneimine Revêtements multicouches Index. décimale : 667.9 Revêtements et enduits Résumé : Magnesium alloy (MgA) was widely used in biomedical field owing to its good biocompatibility and degradability. The surface of MgA was usually modified to improve its corrosion resistance, biocompatibility, and biological properties. Herein, we employed a layer-by-layer assembly technique to assemble both polyanionic and polycationic electrolytes onto the microarc oxidation-treated MgA surface to yield MgA-MgO-PEI-[Ge(HANPs)/Lzm]50, where the gelatin-conjugated hydroxyapatite nanoparticles [Ge(HANPs)] are the polyanionic electrolyte, lysozyme (Lzm) is the polycationic electrolyte, and polyethyleneimine (PEI) is the transition layer. The morphology and chemical composition of MgA-MgO-PEI-[Ge(HANPs)/Lzm]50 were characterized by X-ray diffraction, scanning electron microscopy, and X-ray photoelectron spectroscopy, indicating that [Ge(HANPs)/Lzm]50 were successfully fabricated on the surface of MgA-MgO. The surface of MgA-MgO-PEI-[Ge(HANPs)/Lzm]50 exhibited good hydrophilicity as evidenced by the low water contact angle of 24.5°. Excellent corrosion resistance of MgA-MgO-PEI-[Ge(HANPs)/Lzm]50 was obtained since it can decrease about four orders of magnitude of corrosive current (Icorr) compared to pristine MgA. The biological assay for MgA-MgO-PEI-[Ge(HANPs)/Lzm]50 showed good antiplatelet adhesion and excellent antibacterial activities against both E. coli and S. aureus. Note de contenu : - EXPERIMENTAL : Materials - Preparation of hydroxyapatite nanoparticles (HANPs) - Preparation of MgA with MAO treatment (MgA-MgO - Preparation of MgA-MgO-PEI[Ge(HANPs)/Lzm]50 - Characterizations for morphologies and composition - Water contact angle (WCA) measurement - Potentiodynamic polarization test - Antiplatelets adhesion assay - Antibacterial assay - Determination of release of lysozyme - RESULTS AND DISCUSSION : Morphology and phase structure of HANPs - Morphology and composition of different MgA samples - Hydrophilicity analysis of different MgA samples - Anticorrosive performance of MgA-MgO-PEI[Ge(HANPs)/Lzm]50 - Antiplatelets adhesion assay of MgA-MgO-PEI[Ge(HANPs)/Lzm]50 - Antibacterial assay of MgA-MgO-PEI[Ge(HANPs)/Lzm]50 - Lysozyme release behavior of MgA-MgO-PEI[Ge(HANPs)/Lzm]50 DOI : 10.1007/s11998-018-00162-6 En ligne : https://link.springer.com/content/pdf/10.1007%2Fs11998-018-00162-6.pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=32597 [article]

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