[article]
| Titre : |
Testing the Discriminative Capacity of Compartmental Modeling for the Analysis of the In-Vivo Epidermal Water Content Changes Following Topical Application under Occlusion |
| Type de document : |
texte imprimé |
| Auteurs : |
Pedro Contreiras Pinto, Auteur ; Luis Marcelo Pereira, Auteur ; Rui Minhos, Auteur ; Luis Monteiro Rodrigues, Auteur |
| Année de publication : |
2002 |
| Article en page(s) : |
p. 87-92 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Tags : |
'Skin hydration' 'efficacy testing' 'mthematical modeling' POST 'in-vivo measurement' evaporation 'dynamic water loss' TEWL |
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Mathematical modeling of cutaneous variables is an attratictive strategy to meet the compex nature of in-vivo skin, especially in the presence of an external stimulus such as a topical product. Despite the oversimplification implied, meeting the conceptualization of the model with the representative (physiological) variables is still a major difficulty, often impairing the model validity.
Once achieved, however, its applicability will mostly depend on the demonstration of the accuracy and practicability of the model. In previous works, the authors developed a bi-compartmental model designed to dynamically describe the Trans-epidermal water loss(TEWL) curves obtained in-vivo from the Plastic Occlusion Stress Test (POST) methodology. Occlusion was performed in healthy human volunteers (n=10) occluded with either 10% glycerin in water solution or water alone. Desorption curves allowed to obtain kinetic parameters such as k(evap)(the water evaporation rate at skin surface), t1/2 evap(the evaporation half-life), and DWM (the dynamic water mass) allowing a detailed quantitative description of the hydration process. Results demonstrate that the proposed model is adequate to identify significant differences (p<0.05) between the curve profiles, revealing the different hydration mechanisms involved, and suggesting an interesting application potential for the substantiation and efficacy testing of cosmectics. |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10649 |
in IFSCC MAGAZINE > Vol. 5, N° 2 (04-05-06/2002) . - p. 87-92
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