Epidermal overexpression of stratum corneum chymotryptic enzyme, skin inflammation, and itch / Lennart Hansson in IFSCC MAGAZINE, Vol. 5, N° 4 (10-11-12/2002)

[article]  inIFSCC MAGAZINE > Vol. 5, N° 4 (10-11-12/2002) . - p. 279-283 Titre : Epidermal overexpression of stratum corneum chymotryptic enzyme, skin inflammation, and itch Type de document : texte imprimé Auteurs : Lennart Hansson, Auteur ; Anders Bergman, Auteur ; Annelii Ny, Auteur ; Elisabeth Ekholm, Auteur ; Torbjorn Egelrud, Auteur Année de publication : 2002 Article en page(s) : p. 279-283 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Couche cornée Eczéma constitutionnel Peau -- Inflammation Peau -- Maladies Peptidases Prurits Psoriasis Index. décimale : 668.5 Parfums et cosmétiques Résumé : Identification of tissue-specific mechanisms involved in the pathophysiology of inflammatory skin diseases could offer new possibilities to develop effective therapies with fewer systemic effects. One of the major unmet dermatological problems is itch, which is poorly understood and often difficult to threat. Understanding skin specific targets to identify new technology to ameliorate inflammation and itching is an under researched area but should represent a major market opportunity for both the cosmetic and dermatological industries. Stratum corneum chymotryptic enzyme (SCCE) is a serine protease, which is involved in the proteolytic degradation of corneodesmosomes during desquamation and possibly the activation of pro-inflammatory cytokines such as interleukin-1beta. SCCE is preferentially expressed in cornifying epithelia. It is synthesised by keratinocytes, packaged into the lamellar granules and extruded into the intercellular spaces in the stratum corneum together with the barrier lipids. Here we report on increased epidermal expression of SCCE in psoriasis and atopic dermatitis ; two major chronic inflammatory diseases. In atopic dermatitis, which is often associated with allergic diseases such as rhinoconjunctivitis and asthma, itch is a major symptom. We also pretent our findings on transgenic mice expressing human SCCE in suprabasal epidermal keratinocytes that developed pathologic skin changes similar to the human inflammatory diseases with increased epidermal thickness, hyperkeratosis, dermal inflammtion, impaired barrier function and severe pruritus. These findings indicate that SCCE may be involved in the pathogenesis of inflammatory skin diseases and itch, and that it should be evaluated as potential targets for new therapies. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10628 [article]

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