[article]
| Titre : |
Prevention of UV-induced skin damage by activation of tumor suppressor genes p53 and p14ARF |
| Type de document : |
texte imprimé |
| Auteurs : |
Rolf-Dieter Petersen, Auteur ; John Sabrina, Auteur ; Maria Lueder, Auteur ; Stefan Borchert, Auteur |
| Année de publication : |
2003 |
| Article en page(s) : |
p. 309-315 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Tags : |
'Réparation de l'ADN' 'Vieillissement prématuré' 'Suppression des gênes tumoraux' 'Exposition aux UV' 'Protection |
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
UV-irradiated keratinocytes, pretreated with a soy seed-derived cosmetic active, showed a distinctly reduced decrease in ATP levels, a more effective DNA repair and a reduced formation of irreparable sunburn cells. The search for regulating mechanisms responsible for the results obtained suggested the investigation of the influence of this soy seed active on the tumor suppressor gene p53. Using primary human keratinocytes that were chronically UV-irradiated, it was possible to prove that the soy seed active significantly increased the p53 phosphorylation rate. Only phosphorylated p53, which acts as a transcription factor, can arrest the cell cycle in the case of DNA damage and up-regulated DNA repair or prevent survival of non-reparable cells by inducing apoptosis. In the same cell line it was found that, after chronic UV-irradiation, the soy seed active had stimulated the expression of the tumor suppressor gene p14ARF by more than twice the control rate.
The significance of p14ARF for the functioning of the p53 pathway was recognized only recently. p53 can be down-regulated even in case of severe DNA damage without cell cycle arrest. The responsible factor is the p53 antagonist, the oncoprotein Mdm2. p14ARF as an inhibitor of Mdm2 can subsequently activate p53 and is therefore considered a second defense line in counteracting mutation.
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| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10556 |
in IFSCC MAGAZINE > Vol. 6, N° 4 (10-11-12/2003) . - p. 309-315
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