[article]
| Titre : |
UV-melanogenesis and cosmetic whitening |
| Type de document : |
texte imprimé |
| Auteurs : |
Masamitsu Ichihashi, Auteur ; Yoko Funasaka, Auteur ; Masahiro Oka, Auteur ; Keishi Araki, Auteur ; Hideya Ando, Auteur |
| Année de publication : |
2003 |
| Article en page(s) : |
p. 279-286 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Agents de blanchiment
Mélanocytes
Mélanogénèse
Mélanosome
Peau
Rayonnement ultraviolet
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Pigmented spots that develop in sun-exposed skin, particularly on the face and the dorsa of the hands, are one of the major problems to be treated or prevented by common and functional cosmetics for Asian women having moderate constitutive pigmentation. Recent scientific advances in the understanding of the mechanisms of hyper- and hypo-melanogenesis in animal and human skin have been contributing to the development of novel topical whitening agents as cosmetics. The same applies for the systemic use of drugs and supplements that are expected to regulate melanin synthesis via up-and down-regulation of mRNA of enzymes and oter factors involved, and/or modulating the function of enzymes pivotal in melanogenesis.
In this review, we describe the mechanisms of melanogenesis in relevance to melanosomes, and their transportation and transfer from melanocytes to keratinocytes based on the recent evidence. Further, a role of alphamelanocyte stimulating hormone (α-MSH) and reactive oxygen species (ROS) in UV-melanogenesis is explained focusing on intracellular signal transduction. Finally, future strategy to develop lightening agents for the pigmented skin is discussed, in addition to the introduction of whitening agents previously developed in Japan. |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10545 |
in IFSCC MAGAZINE > Vol. 6, N° 4 (10-11-12/2003) . - p. 279-286
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