| Titre : |
Synergistic effects of taurine and caffeine on regulation of the hair cycle : composition of bioactives against premature hair loss |
| Type de document : |
texte imprimé |
| Auteurs : |
Thomas Welss, Auteur ; Melanie Giesen, Auteur ; Thorsten Knappe, Auteur ; Melanie Briese, Auteur ; Philipp Spuhler, Auteur ; Dirk Petersohn, Auteur ; Thomas Förster, Auteur |
| Année de publication : |
2012 |
| Article en page(s) : |
p. 81-87 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Alopécie
Caféine
Cheveux -- Soins et hygiène
Cuir chevelu -- Soins et hygiène
Produits capillaires
Taurine
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Hair is an attribute of health, youth and attractiveness. Therefore, premature hair loss often is indicative for the well-being of the affected persons. The focus of this study was to identify bioactive substances which counteract premature hair loss by targeted support of the anagen phase of the hair cycle. Therefore, we implemented a test strategy comprising a novel three-dimensional organotypic tissue model of the human dermal papilla for in vitro screening purpose and a noninvasive method to validate the effects in vivo. In the screening approach physiological changes after stimulation with caffeine, taurine or combinations of both were described by analyzing the gene expression of typical anagen and catagen markers (HGF and GFBP-3) as well as the release of the anagen associated growth factor HGF. These results revealed synergistic effects of caffeine and taurine in terms of anagen-stimulatory processes assuming an elongation of the anagen phase. This was additionally supported by analyzing changes in the molecular profiles of anagen-associated HGF protein release and catagen-associated IGFBP-3 gene expression in the plucked hair follicle in vivo after using products containing the active combination. Both methods support the assumption that combination of caffeine and taurine in a hair care composition positively influences hair growth and reduces premature hair loss. |
| Note de contenu : |
- EXPERIMENTAL : Preparation of the reconstructed human dermal papilla - Formulation assisting software toolkit (FAST) - Cytotoxicity in vitro - Differential gene expression - Protein analysis
- RESULTS : Design of experiment - Analysis of cytotoxicity - Analysis of differential gene expression in vitro - Protein analysis in vitro - Evaluation of molecular profile in vivo |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=14956 |
in IFSCC MAGAZINE > Vol. 15, N° 2 (04-05-06/2012) . - p. 81-87
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Synergistic effects of taurine and caffeine on regulation of the hair cycle : composition of bioactives against premature hair loss in IFSCC MAGAZINE, Vol. 15, N° 2 (04-05-06/2012)
