[article]
| Titre : |
Comparison of the biomechanical and biosynthetic behavior of normal human fibroblasts and fibroblasts from a forehead wrinkle |
| Type de document : |
document électronique |
| Auteurs : |
Maud Jouandeaud, Auteur ; Céline Viennet, Auteur ; Sylvie Bordes, Auteur ; Brigitte Closs, Auteur ; Ph. Humbert, Auteur |
| Année de publication : |
2004 |
| Article en page(s) : |
p. 109-113 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Collagène -- Synthèse
Fibroblastes
Peau -- Rides
Peptides
Vitamine C
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Wrinkles are the most obvious expression of skin aging and are manifested by numerous changes in the organization and structure of the dermis. To better understand if this tissue modification could be linked to a modification of cell function, contractile and synthesis capacities of normal aged human fibroblasts and those obtained from a biopsy of a forehead wrinkle were studied and compared. The capacity of fibroblasts to adhere to the collagen network and to maintain a three-dimensional structure of the dermis was studied using a three-dimensional model of a collagen gel. The metabolic activity of both cell types was determined immunochemically by quantifying collagen I synthesis. Human fibroblasts from the wrinkle contracted the collagen gel less than normal aged human fibroblasts and synthesized less collagen I. The results show that the metabolic activity of aging fibroblasts decelerates and that aging fibroblasts lose their capacity to adhere to collagen fibers, thus limiting the possibility of organizing dermal tissue.
The potential of an active ingredient to compensate for the reduction of metabolic activity and to restore the contractile capacity of fibroblasts from the wrinkle was investigated. This effect was compared with a reference molecule, vitamin C. |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10524 |
in IFSCC MAGAZINE > Vol. 7, N° 2 (04-05-06/2004) . - p. 109-113
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