[article]
| Titre : |
Development of effects of plant extracts on the activity and expression of UVA-induced MMPs (matrix metalloproteases) |
| Type de document : |
texte imprimé |
| Auteurs : |
Dong-hwan Lee, Auteur ; Bum-chun Lee, Auteur ; Eun-jeong Yoon, Auteur ; Kyung-eun Lee, Auteur ; Sung-min Park, Auteur ; Hyeong-bae Pyo, Auteur ; Tae-boo Choe, Auteur |
| Année de publication : |
2004 |
| Article en page(s) : |
p. 227-231 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Tags : |
MMP UVA 'Extraits de plante' 'Tussilago farfara' 'Dicentra spectabilis' |
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
The effects of several natural products on in vitro MMP-1 activity and UVA-induced MMP-1 synthesis in human dermal fibroblast (HDF) cultures were studied with the aim of developing novel anti-aging agents from natural sources. We measured MMP-1 activities by fluorescence assay using gelatin as substrates. In addition, UVA-induced MMP-1 expression was analyzed by enzyme-linked immunosorbent assay (ELISA) and gelatin-based zymography in HDF cultures, and RT-PCR techniques were used. The results showed a strong inhibitory effect of the extracts of Dicentra spectabilis and of the flower buds of Tussilago farfara. In a concentration of 0.05% (w/v), the extracts of the flower buds of Tussilago farfara and of Dicentra spectabilis inhibited MMP-1 activity by 92 and 87% respectively. At 0.1% (w/v), the extracts of the flower buds of Tussilago farfara and of Dicentra spectabilis suppressed the UVA-induced expression of MMP-1 by an amount similar to that with Vitamin C 200 μm. These results suggest that the extracts of Dicentra spectabilis and of the flower buds of Tussilago farfara effectively protect skin from UV-induced photoaging. Therefore, the extracts are thought to have potential as effective raw materials for anti-aging cosmetics. |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10480 |
in IFSCC MAGAZINE > Vol. 7, N° 3 (07-08-09/2004) . - p. 227-231
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