Relationship between lip skin biophysical and biochemical characteristics with corneocyte unevenness ratio as a new parameter to assess the severity of lip scaling / Jongwook Kim in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 43, N° 3 (06/2021)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 43, N° 3 (06/2021) . - p. 275-282 Titre : Relationship between lip skin biophysical and biochemical characteristics with corneocyte unevenness ratio as a new parameter to assess the severity of lip scaling Type de document : document électronique Auteurs : Jongwook Kim, Auteur ; Hyerin Yeo, Auteur ; Taeyoon Kim, Auteur ; Eui-Taek Jeong, Auteur ; Jun M. Lim, Auteur ; Sun-Gyoo Park, Auteur Année de publication : 2021 Article en page(s) : p. 275-282 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Barrière cutanée Hydratation Peau -- Physiologie Peptidases Sécheresse cutanée Une xérose est un dessèchement de la peau. Elle peut avoir différentes causes, comme certaines pathologies (dermatite atopique aussi appelé eczéma atopique), des carences, notamment en Vitamine A, ou des facteurs externes, comme les contacts avec des substances irritantes ou le traitement par certains médicaments. Statistique Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Lip skin dryness and chapping are major concerns related to lip skin care in many populations. The distinctive features of lip skin, such as the low water-holding capacity and weak skin barrier, are strongly associated with these problems; however, few studies have examined lip skin characteristics and the mechanisms underlying these issues. This study was conducted to identify the biophysical properties of dry lip skin and molecular targets affecting lip skin physiology. - Methods : Skin hydration, transepidermal water loss and lip skin scaling were evaluated in 40 female subjects. Skin scaling was assessed as a percentage area divided into five categories (G0, G1, G2, G3 and G4) according to the thickness level of tape-stripped corneocytes. The activities and amounts of proteases, cathepsin D and bleomycin hydrolase were measured as markers for the desquamation process and skin hydration, respectively. - Results : Skin hydration showed a significantly positive correlation with the percentage area of evenly thin corneocytes (G0) and negative correlations with the percentage areas of slightly thick to severely thick corneocytes (G1-G4). The corneocyte unevenness ratio (CUR) was calculated by dividing the sum of the G1, G2, G3 and G4 values with the G0 value. The CUR was significantly negatively correlated with skin hydration, suggesting that CUR is a new parameter representing the severity of lip scaling. Subjects with lower hydration and higher CUR had higher bleomycin hydrolase activity and lower cathepsin D activity, respectively, than subjects with higher hydration and lower CUR. - Conclusion : Our study revealed a correlation between lip skin hydration and severity of lip scaling and verified the association of protease activity with the hydration and chapping state of lip skin. These observations provide a basis for further studies of the persistent problem of lip skin dryness and chapping. Note de contenu : - MATERIALS AND METHODS : Subjects - Biophysical measurements - Protein extraction from the lip skin - Measurement of protease activity - Quantification of protease concentrations - Statistical analysis - RESULTS : Correlations between lip dryness-related biophysical parameters - Differences in activities and amounts of proteases related to lip skin hydration - Differences in activities and amounts of proteases related to chapping of lip skin - Table 1 : Correlation coefficients between skin biophysical parameters DOI : https://doi.org/10.1111/ics.12692 En ligne : https://drive.google.com/file/d/1xW30jfvxocMUqLYIRUc5wte31j41fDuy/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35894 [article]

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The penetration enhancement and the lipolytic effects of TAT–GKH, both in in vitro, ex vivo, and in vivo / Jun-Man Lim in IFSCC MAGAZINE, Vol. 7, N° 2 (04-05-06/2004)

[article]  inIFSCC MAGAZINE > Vol. 7, N° 2 (04-05-06/2004) . - p. 103-108 Titre : The penetration enhancement and the lipolytic effects of TAT–GKH, both in in vitro, ex vivo, and in vivo Type de document : document électronique Auteurs : Jun-Man Lim, Auteur ; Min-Youl Chang, Auteur ; Sun-Gyoo Park, Auteur ; Nae-Gyu Kang, Auteur ; Young-sook Song, Auteur ; Yun-Seog Kang, Auteur ; Wan-Goo Cho, Auteur Année de publication : 2004 Article en page(s) : p. 103-108 Note générale : Bibliogr. Langues : Anglais (eng) Tags : Adipocyte  'Cellules  de  diffusion  Franz'  'Système  projection  Fringe'  Lipolyse  Microdialyse  'Tri-peptide  glycine–lysine–histidine'  'Activateur  transcriptionnel  Transactivation' Index. décimale : 668.5 Parfums et cosmétiques Résumé : It was demonstrated that the trans-activating transcriptional activator (TAT) protein from HIV-1 could enter cells when added to the surrounding media. TAT peptide chemically attached to various proteins was able to deliver these proteins to various cells and even at high levels in heart and spleen tissues in mice. In this study, the tri-peptide GKH (glycine–lysine–histidine) derived from the parathyroid hormone, which is known as a lipolytic peptide, was attached to 9-poly lysine (TAT) to be used as a cosmetic ingredient for eye-bag care product. When glycerol is released, expressed as the extracellular glycerol concentration (the so-called lipolysis index), TAT–GKH at 10−5m induces a maximal lipolytic effect of approximately 41.5% in epididymal adipocytes isolated from rats, compared with basal lipolysis. In a microdialysis study, TAT–GKH was perfused into epididymal adipose tissues of anaesthetized rats in increasing concentrations in a Ringer solution. The glycerol concentration in each dialysate was measured using an ultra-sensitive radiometric method. The perfusion of TAT–GKH induced a lipolytic effect. A penetration study showed that TAT–GKH resulted in a sevenfold higher penetration into excised hairless mice skin than GKH. An in vivo study showed that a TAT–GKH containing emulsion had a better effect upon the relative volume reduction of eye bag after 28 days of application on 22 healthy female volunteers than the placebo. It was therefore concluded that TAT–GKH increased skin penetration, which resulted in enhanced lipolytic effects in in vitro, ex vivo and in volume reduction of eye-bags in in vivo studies. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10523 [article]

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