| Titre : |
Thermally responsive collagen switching from bactericidal for ambient storage condition to biologically inert in vivo |
| Type de document : |
texte imprimé |
| Auteurs : |
Jinming Chang, Auteur ; Zhou Xu, Auteur ; Gaofu Yang, Auteur ; Zhonghui Wang, Auteur ; Yi Chen, Auteur ; Haojun Fan, Auteur |
| Année de publication : |
2018 |
| Article en page(s) : |
p. 114-121 |
| Note générale : |
Bibliogr. |
| Langues : |
Américain (ame) |
| Catégories : |
Antimicrobiens
Collagène -- Conservation
Composés organiques -- Synthèse
Poly(n-isopropylacrylamide)
|
| Index. décimale : |
675 Technologie du cuir et de la fourrure |
| Résumé : |
Incorporating preservatives is now the most commonly employed strategy to prevent microbial deterioration of collagen. However, many preservatives are non-selective; they cannot differentiate the orthologs in mammalian cells from their biological targets in pathogens, and thus their incorporation compromises the inherent biocompatibility of naturally occurring collagen. Here, we report a strategy to covalently anchor antibacterial agents to collagen via a thermally responsive poly(N-isopropylacrylamide) spacer. As the spacer suddenly collapses from an extended coil upon heating through ~30°C, bioactivity of the anchored antibacterial agents can be switched off, because their lateral mobility and, hence, target-site accessibility are restricted. Accordingly, the modified collagen can be preserved without microbial deterioration for ambient storage condition, while imposing no cytotoxic impact upon surrounding tissues in vivo. This thermally responsive collagen holds great potential in biomedical fields, where the collagen products are intended to have intimate contact with human tissues or be administered parenterally. |
| Note de contenu : |
- Materials
- Synthesis of NHS ester-activated RAFT agent
- Synthesis of N-acryloyl ciprofloxacin
- Synthesis of PNIPAM-ciprofloxacin conjugate
- Covalent anchoring of PNIPAM-ciprofloxacin conjugate onto collage
- Characterization |
| En ligne : |
https://drive.google.com/file/d/1tQt8XtEUmJ7NxBB2IyUcepNHuJXcEXyK/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=30340 |
in JOURNAL OF THE AMERICAN LEATHER CHEMISTS ASSOCIATION (JALCA) > Vol. CXIII, N° 4 (04/2018) . - p. 114-121
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