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In vivo study of age-related skin changes using in vivo confocal microscopy / Isabelle Imbert in IFSCC MAGAZINE, Vol. 15, N° 1 (01-02/2012)
[article]
Titre : In vivo study of age-related skin changes using in vivo confocal microscopy Type de document : texte imprimé Auteurs : Isabelle Imbert, Auteur ; Yolène Ferreira-Guérif, Auteur ; Gilles Oberto, Auteur ; Arlette Berghi, Auteur ; Paul Mouser, Auteur ; Karine Cucumel, Auteur ; Nouha Domloge, Auteur Année de publication : 2012 Article en page(s) : p. 15-21 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Microscopie confocale
Vieillissement cutanéIndex. décimale : 668.5 Parfums et cosmétiques Résumé : In the past decade laser-scanning confocal microscopy was developed as a non-invasive method providing in vivo images of human skin in real time. The aim of the study was to observe and measure skin changes due to aging using in vivo confocal microscopy. Several parameters were analyzed such as stratum corneum and epidermal thickness, spinous and granular cell morphology, number, heigh and morphology of dermal papillae, and finally the collagen aspect. Twenty-five volunteers aged 20 to 70 were enrolled in this study. Calculation of the correlation coefficient (r) demonstrated that the stratum corneum thickness and the epidermal thickness were very strongly linked to age. Observed with aging were cell disorganization, cell spreading as well as numerous cells showing irregular shapes and vacuoles. The number and height of dermal papillae showed a statistically significant reversed correlation with aging, suggesting that dermal papillae are a good indicator of aging. In the younger groups collagen bundles were compact and dense, while in older groups filiform collagen bundles were observed. Finally, based on the method previously described, we assayed compound IV08.009, a peptide designed to improve the epidermal niche, in an in vivo double blind study. We showed significant in vivo benefits such as an increase in the number of papillae and in the theoretical age in the group of volunteers after 28 days of treatment. Note de contenu : - EXPERIMENTAL : Methodology - Volunteers - Measurement of stratum corneum thickness - Measurement of epidermal thickness - Number and height of dermal papillae - Statistical analysis - Clinical study
- RESULTS : Epidermal and stratum corneum thickness - Measurement of dermal papillae (heigh and number) - Observation of collagen fibers - Benefit of biofunctional compound IV08.009 for dermal papillaPermalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=13670
in IFSCC MAGAZINE > Vol. 15, N° 1 (01-02/2012) . - p. 15-21[article]Réservation
Réserver ce documentA sirtuin activating biofunctional fights ageing / Karine Cucumel in PERSONAL CARE EUROPE, Vol. 3, N° 4 (11/2010)
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Titre : A sirtuin activating biofunctional fights ageing Type de document : texte imprimé Auteurs : Karine Cucumel, Auteur ; Yolène Ferreira-Guérif, Auteur ; Gilles Oberto, Auteur ; Paul Mouser, Auteur ; Claude Dal Farra, Auteur ; Nouha Domloge, Auteur Année de publication : 2010 Article en page(s) : p. 54-56 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge
Cosmétiques
Peau -- Effet du rayonnement ultraviolet
Sirtuines
Vieillissement cutanéIndex. décimale : 668.5 Parfums et cosmétiques Résumé : Ageing is a process in which both intrinsic and extrinsic determinants lead to the accumulation of unrepaired damage to cellular and organismal components over time. Ultraviolet (UV) irradiation considerably accelerates the visible signs of skin ageing and photodamage is believed to account for 80% of facial ageing. En ligne : https://drive.google.com/file/d/1CEkm_4AAFmlAe4CV-mlkAtbR1Zaw6TBL/view?usp=drive [...] Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10265
in PERSONAL CARE EUROPE > Vol. 3, N° 4 (11/2010) . - p. 54-56[article]Réservation
Réserver ce documentThe beauty of biodesign : new frontier for collagen / Paul Mouser in GLOBAL PERSONAL CARE, Vol. 24, N° 3 (03/2023)
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Titre : The beauty of biodesign : new frontier for collagen Type de document : texte imprimé Auteurs : Paul Mouser, Auteur ; Erin Turner, Auteur ; Michela Caffrey, Auteur ; Nick Ouzounov, Auteur Année de publication : 2023 Article en page(s) : p. 73-76 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge
Biotechnologie
Collagène
Collagène -- Synthèse
Dermo-cosmétologie
Hyaluronique, acideL'acide hyaluronique est un type de polysaccharide (plus précisément une glycosaminoglycane) non fixé à une protéine centrale et largement réparti parmi les tissus conjonctifs, épithéliaux et nerveux animaux.
Il se trouve notamment dans l'humeur vitrée et le liquide synovial. Il est l'un des principaux composants de la matrice extracellulaire ainsi que de certaines mucoprotéines lorsqu'il est associé à une fraction protéique.
Depuis les années 1990, il est très utilisé dans divers dispositifs médicaux, médicamenteux et cosmétiques (présenté dans ce dernier cas comme "antistatique, humectant, hydratant, conditionneur cutané, anti-âge, etc."), bénéficiant d'un effet de mode grandement soutenu par une large publicité commerciale.
Contribuant de façon significative à la prolifération et à la migration des cellules, l'acide hyaluronique est aussi impliqué dans la progression de certains cancers. (Wikipedia)
Ingrédients cosmétiques
Peau -- Soins et hygièneIndex. décimale : 668.5 Parfums et cosmétiques Résumé : Today's beauty consumer demands sustainable, animal-free, and performance driven products. These shifting sentiments put active ingredients in the spotlight and demand innovation. Biodesign is rising to the challenge. This approach to product development combines advances in computational biology and precision fermentation to deliver the best of nature's depth and diversity to consumers. White many are familiar with biotechnology's first breakthrough ingredient — hyaluronic acid (HA) — proteins like collagen have rapidly emerged as the pioneering products enabled by biodesign.
HA from microbial fermentation paved the way for future fermentation-derived bioactive ingredients. In 1998 scientists at Savient Pharmaceuticals successfully produced high molecular weight HA, historically sourced from rooster combs, through precision fermentation of the microorganism Streptococcus zooepidemicus' Biotechnology unlocked the potential to create sustainable alternatives to animal-derived molecules that eliminate unethical practices, complicated supply chains, and the use of environmentally harsh chemical processes.
Collagen is another popular ingredient in beauty and an important target for biodesign as it is the most abundant protein in the human body, responsible for structure, stability, and strength within the dermal layers. In addition to its essential structural function, collagen is a signaling molecule defining cellular activities.
There are at least 28 types of collagen identified in the body, all sharing a common triple helix structure yet differing in a- chain composition.Note de contenu : - ECM stimulation - in vitro
- ECM stimulation - in vivo
- Endogenous production of HAEn ligne : https://drive.google.com/file/d/1Li5Umjr68-AgSK7CTMRg_ernPoYd-Fso/view?usp=drive [...] Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38985
in GLOBAL PERSONAL CARE > Vol. 24, N° 3 (03/2023) . - p. 73-76[article]Réservation
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