[article]
| Titre : |
Effects of pomegranate flower complex on the skin |
| Type de document : |
texte imprimé |
| Auteurs : |
Julian Smits, Auteur ; Norbert Herbst, Auteur |
| Année de publication : |
2012 |
| Article en page(s) : |
p. 25-30 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Antiâge:Antirides
Antioxydants
Collagène -- Synthèse
Extraits de plantes:Extraits (pharmacie)
Fruits -- Emploi en cosmétologie
Grenadier et constituants
Phosphate ascorbylique de sodium
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
The balance between collagen breakdown and collagen synthesis plays a crucial role in the extrinsic and intrinsic process of skin ageing. Environmental factors acting on the skin and genetically-determined processes cause an increase in collagen breakdown and at the same time a reduction in the synthesis of new collagen, which results in the increased appearance of wrinkles. One of the enzymes responsible for the breakdown of collagen is matrix metalloproteinase 1 (MMP-1). It has been demonstrated that an extract of pomegranate flowers reduces MMP-1 mRNA gene expression in UVA irradiated and non-irradiated primary human dermal fibroblasts. Due to this characteristic, the pomegranate flower extract (PGFE) was combined with sodium ascorbyl phosphate (SAP) into a single product (PGFE/SAP). SAP, a derivative of vitamin C, is a wellknown antioxidant and collagen booster. The combined product made of PGFE and SAP (PGFE/SAP) was successfully tested for its safety in use both in vitro and in vivo. Results showed that PGFE/SAP promoted collagen synthesis, reduced the breakdown of collagen and measurability and visibly reduced the depth of facial wrinkles caused by skin ageing. |
| Note de contenu : |
- MATERIAL AND METHODS : MMP-1 gene expression analysis - MMP-1 synthesis (ELISA) - UV cytotoxicity assay - Product manufacture - Application formula - Tests concerning product safety - In vivo studies - Ultrasonography - Profilometry (PRIMOS) - Visual evaluation (VisioFace Quick)
- RESULTS : Product safety (cytotoxicity, phototoxicity, mutagenicity, eye iritation (HET CAM), skin iritation (SPT/RPT), allergy research) - In vitro (MMP-1 gene expression analysis (RT-PCR), UV cytotoxicity, MMP-1 synthesis (ELISA), in vivo (skin density measurement using ultrasonography, profilometry (PRIMOS), visual evaluation (VisioFace Quick) |
| En ligne : |
https://drive.google.com/file/d/1iKAqJcPNV0DsFXchyKz6meJaQwV1kbnP/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=13392 |
in PERSONAL CARE EUROPE > Vol. 5, N° 1 (02/2012) . - p. 25-30
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Effects of pomegranate flower complex on the skin in PERSONAL CARE EUROPE, Vol. 5, N° 1 (02/2012)
