Artificial neural network modeling of tablet coating in a pan coater / Assia Benayache in JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH, Vol. 20, N° 2 (03/2023)  

[article]  inJOURNAL OF COATINGS TECHNOLOGY AND RESEARCH > Vol. 20, N° 2 (03/2023) . - p. 485-499 Titre : Artificial neural network modeling of tablet coating in a pan coater Type de document : texte imprimé Auteurs : Assia Benayache, Auteur ; Lynda Lamoudi, Auteur ; Kamel Daoud, Auteur Année de publication : 2023 Article en page(s) : p. 485-499 Note générale : Bibliogr. Langues : Américain (ame) Catégories : Caractérisation Comprimés Enrobage pharmaceutique Ethylcellulose Matériaux -- Epaisseur Réseaux neuronaux (informatique) Revêtements organiques Index. décimale : 667.9 Revêtements et enduits Résumé : Our study decided to use the new and revolutionary approach in the field of pharmaceutical coating processes called the artificial neural network (ANN) by using the neural networks toolbox derived from the Matlab® software. The experiments were performed using tablets of Alfuzosin Chlorhydrate as a model filler, and an aqueous solution of Surelease as a polymer in different contents. The various parameters that can affect coating thickness, weight gain, and the coefficient of variation CV, such as spray rate, air pressure, solid content, speed of the drum, pan loading, and time of coating, were studied. The properties of the coated tablets were evaluated using the ANN, and both the parameters of the coating process and the properties of the coated tablets were used as a basis for optimization, as well as the choice of the optimal structure of the ANN model. It was found that the best neural network architecture had 7 neurons in the hidden layer, with a mean square error of 3.515 and a determination coefficient of nearly 1. The relative importance of each independent variable was quantified using the Garson equation. In this study, spray rate was found to have the highest impact on the properties of tablets. Note de contenu : - MATERIALS AND METHODS : Characterization of core tablets - Coating dispersion - Coating process - Characterization of the coating solution - Characterization of coating tablets - RESULTS AND DISCUSSION : Model architecture and prediction - Relative importance of input variables - The influence of parameters on the properties of coating tablets - Optimization of coating tablets - Table 1 : Effect of solids concentration on the viscosity, density, and surface tension of coating fluids measured coating - Table 2 : Variable parameters - Table 3 : ANN model's weight and bias matrix - Table 4 : Effects of coating parameters on the relative standard deviation at the final process stage - Table 5 : Ideal values of inputs, predicted and experimental values of outputs DOI : https://doi.org/10.1007/s11998-022-00683-1 En ligne : https://link.springer.com/content/pdf/10.1007/s11998-022-00683-1.pdf?pdf=button Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=39293 [article]

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Coating potential of a new modified starch coating for immediate release oral tablets / Tareq A. Rumman in JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH, Vol. 12, N° 1 (01/2015)  

[article]  inJOURNAL OF COATINGS TECHNOLOGY AND RESEARCH > Vol. 12, N° 1 (01/2015) . - p. 167-175 Titre : Coating potential of a new modified starch coating for immediate release oral tablets Type de document : texte imprimé Auteurs : Tareq A. Rumman, Auteur ; Israa H. Al-Ani, Auteur ; Samira F. Hassan, Auteur Année de publication : 2015 Article en page(s) : p. 167-175 Note générale : Bibliogr. Langues : Américain (ame) Catégories : Alcool polyvinylique Amidon modifié Caractérisation Comprimés Couches minces Couches minces -- Propriétés mécaniques Diffusion (physique) Dispersions et suspensions Essais (technologie) Hydroxypropyl méthylcellulose Perméabilité Revêtements poudre Index. décimale : 667.9 Revêtements et enduits Résumé : Film coating of tablets is the application of a thin layer of coating material to improve the tablet properties. Different coating materials like hydroxypropyl methylcellulose (HPMC) and polyvinyl alcohol (PVA) have been widely used in tablet coatings for immediate release of the active pharmaceutical ingredient. A new immediate release film coating formula that contains modified corn starch as the coating polymer was investigated, and it shows improved physiochemical properties over conventional film coating material (HPMC and PVA). The purpose of this study is to investigate the potential of the new modified starch coating as a coating material in comparison with HPMC- and PVA-based formulas. Evaluation was done on a coating powder dispersion of 20% w/w by measuring the viscosity, sedimentation, foaming behavior, and microbial stability. Free films were prepared from each coating formula and tested for water vapor permeability and morphology. The coating process was then executed on the model tablets (levofloxacin 500 mg) after optimizing the coating parameters. Characterization of modified starch film-coated tablets was done by testing morphology, hardness, friability, thickness, disintegration, and drug release profiles. It was concluded that the new modified starch coating is superior to HPMC and PVA formulations in terms of free film and applied coated tablet esthetics, inner structure composition, preparation and coating process parameters. Additionally, the modified starch coating showed similar release profiles to HPMC- and PVA-based coating formulas. Note de contenu : - Coating dispersion study - Free film analysis - Coating process - Characterization of coated tablets compared with uncoated tablets - Drug release from modified starch-coated tablets in different storage conditions DOI : 10.1007/s11998-014-9618-3 En ligne : https://link.springer.com/content/pdf/10.1007%2Fs11998-014-9618-3.pdf Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=23215 [article]

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A critical review of techniques and technology of tablet coating / Nana Satpute in PAINTINDIA, Vol. LXXII, N° 10 (10/2022)  

[article]  inPAINTINDIA > Vol. LXXII, N° 10 (10/2022) . - p. 70-77 Titre : A critical review of techniques and technology of tablet coating Type de document : texte imprimé Auteurs : Nana Satpute, Auteur ; Ganesh Zade, Auteur Année de publication : 2022 Article en page(s) : p. 70-77 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Comprimés Enrobage (technologie) Enrobage pharmaceutique Evaluation Fluidisation Liants Pigments Plastifiants Polymères Revêtements organiques solvants Index. décimale : 667.9 Revêtements et enduits Résumé : Pharmaceutical drug coatings are highly advantageous and considerable development has recently happened to enhance the quality of the tablet. Tablet coating is carried out for the purposes such as decoration and protection of tablets along with some functional properties. The coating is a homogeneous mixture of polymeric material ; a very thin layer is applied on a substrate of the drug by using various techniques. These coatings techniques are either manually operated or fully automated. The automatic process gives coating with more uniform film properties at a high production rate. The coating is the last unit operation in the manufacturing of drugs in the pharmaceutical industries. Tablet coating involves the use of various binders, colour forming agents (colorants), organic solvents and plasticizers to get the required characteristics. Coating a tablet is always a great challenge to coating a formulator as it involves various statutory requirements to qualify as well as technically it also performs well against various environmental changes. Coating plays a key role in the pharma industry to protect the drugs from different environmental challenges like changes in humidity, light, heat etc. Now a days in coating application industries various new coating techniques are available like spray and fluidised bed methods that are developed to overcome the limitations of old techniques. This review paper focuses on the various aspects of various raw materials, types of tablet coating, processes of tablet coatings, defects and remedies of tablet coatings etc. Note de contenu : - PURPOSE OF COATING THE TABLET - TABLET COATING MECHANISM : Types of coatings - Sugar coating - FILM COATING - RESIN - PIGMENTS : Requirements of good pigment - PLASTICIZER - SOLVENT : Requirements of good solvent - Advantages of film coating over sugar coatings - Tablet coating defects and remedies - Colour variation - Orange peel - Blooming - Twinning - BListering/pinholes - Cracking - Chipping - EVALUATION OF TABLET COATING - ASPECTS OF TABLE COATING CHARACTERISATION - Fig. 1 : Electrostatic dry coating system - Fig. 2 : Classification of pigments - Fig. 3 : Film coating process flow diagram En ligne : https://drive.google.com/file/d/10h7iu-swNzc7oRVBjKC-cWyRuyx732mn/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38539 [article]

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Formulations in GLOBAL PERSONAL CARE, Vol. 25, N° 4 (04/2024)  

[article]  inGLOBAL PERSONAL CARE > Vol. 25, N° 4 (04/2024) . - p. 135-138 Titre : Formulations Type de document : texte imprimé Année de publication : 2024 Article en page(s) : p. 135-138 Note générale : Fiches formulations Langues : Anglais (eng) Catégories : Antiâge:Antirides Comprimés Conditionneurs (cosmétique) Crayons cosmétiques Dentifrices Dermo-cosmétologie Détoxication métabolique d'une substance Fond de teint Formulation (Génie chimique) Masques (cosmétique) Pâteux (ingrédients cosmétiques) Peau -- Soins et hygiène Produits antisolaires Produits hydratants Index. décimale : 668.5 Parfums et cosmétiques Résumé : 15 marques présentent chacune la formulation d'un produit cosmétique. Note de contenu : - BRB : Scar gel - CARGILL BEAUTY : Satin hug body cream - CARRIBEAN NATURAL PRODUCTS : Sunscreen finished - DSM-FIRMENICH : Hya-act in & on wrinkle filler serum - ELEMENTIS : Cream to powder foundation - GATTEFOSSE : Ma'caring primer - KOSTER KEUNEN : Sustainable Bath crayon - INGREDION : Fresh bite toothpaste tablets - LIPOID KOSMETIK : Gentle repair hand cream - NAGASE VIITA : Super C serum - NATURA-TEC : increadibly passionate mask - NOURYON : The bar necessities conditioner - OLVEA : Feel good solid moisturizer - PRAAN NATURLAS : Whipped polynesian coconut body butter - SALICYLATES & CHEMICALS : Skin detoxifying mousse with SPF-50 En ligne : https://drive.google.com/file/d/1E6HX9uIzf7AlUHeTgq31Sfk7kpQ80sAs/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=41051 [article]

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Leachable pegylated cellulose acetate complex: a promising approach for controlled porosity osmotic pump tablets of Captopril / Muhammad Faheem Akhtar in JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH, Vol. 17, N° 2 (03/2020)  

[article]  inJOURNAL OF COATINGS TECHNOLOGY AND RESEARCH > Vol. 17, N° 2 (03/2020) . - p. 439-446 Titre : Leachable pegylated cellulose acetate complex: a promising approach for controlled porosity osmotic pump tablets of Captopril Type de document : texte imprimé Auteurs : Muhammad Faheem Akhtar, Auteur ; Muhammad Hanif, Auteur Année de publication : 2020 Article en page(s) : p. 439-446 Note générale : Bibliogr. Langues : Américain (ame) Catégories : Acétate de cellulose L'acétate de cellulose est une matière plastique inventée en 1865. C'est l'ester acétate de la cellulose. Comprimés Formulation (Génie chimique) Osmolalité Polyéthylène glycol Sorbitol Index. décimale : 667.9 Revêtements et enduits Résumé : The aim of the present study was to develop pegylated cellulose acetate coating layer having leachable membrane created by controlled porosity osmotic pump (CPOP) technique. Already optimized core tablets of Captopril were used for the application of CPOP. In Box–Behnken design, cellulose acetate, polyethylene glycol, and sorbitol were used as variables and %Captopril release as a response for the coating process. Formulations were characterized by weight gain, thickness of leachable membrane, content uniformity, drug release, pH, dissolution medium osmolality effect, FTIR, and stability analysis for the optimization purpose. Optimized formulation was within the pharmacopoeial limits. Observed weight gain was 4.38–6.97%, and thickness of leachable membrane was 1.24–1.47 mm. Content uniformity was found to be 91.65–99.61%. Phosphate buffer of pH 6.8 showed 86.22–92.79% drug release and the first-order release pattern. pH-independent but osmolality-dependent drug release was observed. No incompatibility between the ingredients of prepared dosage form was observed in FTIR analysis. Accelerated stability study for 6 months showed no significant change in the prepared dosage form. Conclusively, prepared CPOP tablets can be used for the controlled release of Captopril in hypertensive patients to maintain the desired drug concentration within the body for required time period. Note de contenu : - MATERIALS AND METHODS : Materials - METHODS : Experimental design - Formulation of CPOP tablets - Physical evaluation of CPOP tablets - Content uniformity - Drug release kinetics - effect of dissolution medium osmolaty on %captopril release - Effect of pH on %captopril release - FTIR spectroscopic analysis - Stability study statistical analysis - RESULTS AND DISCUSSION : Physicochemical process of CPOP tablets - Content uniformity of CPOP tablets - Drug release kinetics for CPOP tablets - Effect of dissolution medium osmolality on %captopril relase - Effect of pH on %captopril release - FTIR spectroscopic analysis - Stability study DOI : https://doi.org/10.1007/s11998-019-00290-7 En ligne : https://link.springer.com/content/pdf/10.1007/s11998-019-00290-7.pdf Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=33994 [article]

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Modified smart collagen biomaterials for pharmacy and adhesive applications / Ján Matyasovsky in JOURNAL OF THE AMERICAN LEATHER CHEMISTS ASSOCIATION (JALCA), Vol. CXI, N° 10 (10/2016)  

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Optimization of film-coating formulation containing a novel low molecular weight hypromellose to achieve balanced tablet-coating performance / Hao Gao in JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH, Vol. 14, N° 5 (09/2017)  

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