Investigation of the reductive metabolism of the azo dye "coriacide black SB" in rats / M. K. Ellis in JOURNAL OF THE SOCIETY OF LEATHER TECHNOLOGISTS & CHEMISTS (JSLTC), Vol. 81, N° 2 (03-04/1997)  

[article]  inJOURNAL OF THE SOCIETY OF LEATHER TECHNOLOGISTS & CHEMISTS (JSLTC) > Vol. 81, N° 2 (03-04/1997) . - p. 52-56 Titre : Investigation of the reductive metabolism of the azo dye "coriacide black SB" in rats Type de document : texte imprimé Auteurs : M. K. Ellis, Auteur ; G. J. McPherson, Auteur ; N. Ashcroft, Auteur Année de publication : 1997 Article en page(s) : p. 52-56 Note générale : Bibliogr. Langues : Anglais (eng) Index. décimale : 547.86 Colorants et pigments Résumé : Azo colorants may undergo in vivo reduction of the azo group to release amines, some of which, through subsequent metabolic activation, are considered to be carcinogenic. Thus, all azo colorants whose metabolism can potentially liberate a carcinogenic amine are suspected of having a similar carcinogenic potential. Chemical methods used to assess the likely production of such amines use reductants such as sodiumdithionite or Raney Nickel. A recent investigation of the applicability of the use of these strong chemical reductants to force azo fission questions their suitability for certain classes of azo colorants. In particular potentially non-carcinogenic aniline-based azo dyes were found to release trace amounts of the known human carcinogen 4-aminodiphenyl, even though this amine is absent before reduction. To assess the potential for the enzymatic formation of 4-aminodiphenyl in vivo, we have compared the reductive biotransformation of the aniline-azo-linked dy Coriacide Black SB with that of a 4-aminodiphenyl-azo-linked analogues in rats. 4-Aminodiphenyl could not be detected in the urine of rats administered Coriacide Black SB, whereas this amine was detected in the urine of rats administered the 4-aminodiphenyl-azo-linked analogue. This finding suports evidence that the 4-aminodiphenyl detected following the chemical reduction of dyes incorporating aniline as the azo component is an artefact of the reduction conditions and would not occur in vivo. En ligne : https://drive.google.com/file/d/1P5d-vIaYieQupED9WZg3_PgMBhdrr0Cl/view?usp=share [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=8053 [article]

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