[article]
| Titre : |
Stress, Apoptosis and Ageing in Human Skin |
| Type de document : |
texte imprimé |
| Auteurs : |
Jean-Luc Contet-Audonneau, Auteur ; Louis Danoux, Auteur ; D. Gauché, Auteur ; G. Pauly, Auteur |
| Année de publication : |
2001 |
| Article en page(s) : |
p. 115-124 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Skin is exposed to a great number of different stress factors which can lead to structural and biological damages. In the case of important lesions, apoptosis is the witness of all these events and also a good marker of cell alterations. It is important to bring a good protection to these cells with active ingredients that can decrease the effect of these stresses.
Our goal was to use different techniques of human cell cultures in-vitro and human skin explants ex-vivo to quantify apoptotic lesions induced by different stresses, to identify a couple of specifiq markers, and to select some active plant extracts acting against these stresses.
First we have used the cell culture technique to estimate the apoptotic lesions provoked by different types of stress. Then we have confirmed these apoptotic lesions in human skin explants and identified 4 markers of apoptotic steps characteristic for our test conditions : Fas, APO 2.7, p53 and TUNEL technique.
To study the ageing of skin we have used an original model of skin explants ex-vivo with deprivation of growth factors, similar to the deficiency found in ageing organs[5].
Finally in our search for new products, we found some active plant extracts which can prevent apoptotic cell lesions. In particular A.P.S. provided a good protection against lesions provoked by exhaust gas, and extracts of Cassia and Vigna provided a cytophotoprotection effect (against UV-irradiation) and an anti-ageing effect (against deprivation of growth factors) to epidermal cells. |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10740 |
in IFSCC MAGAZINE > Vol. 4, N° 2 (04-05-06/2001) . - p. 115-124
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Stress, Apoptosis and Ageing in Human Skin in IFSCC MAGAZINE, Vol. 4, N° 2 (04-05-06/2001)
