[article]
| Titre : |
Eugenyl glucoside as an active ingredient for hair re-growth agent : release of eugenol from eugenyl glucoside on human scalp and 5alpha-reductase inhibitory effect |
| Type de document : |
texte imprimé |
| Auteurs : |
Kazuto Hamada, Auteur ; Uchiwa Hideyo, Auteur ; Takeshi Ikemoto, Auteur ; Hiroyuki Nishio, Auteur ; Hirofumi Kuwahara, Auteur ; Yasushi Watanabe, Auteur |
| Année de publication : |
2001 |
| Article en page(s) : |
p. 83-87 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Tags : |
'Eugenyl glucoside' Eugenol Clove 'Release control' Anti-androgen '5alpha-reductase inhibitor' 'Androgenetic alopecia' 'Hair re-growth' |
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Clove bud oil is an important natural essential oil known to be effective in activating hair growth as well as blackening gray hair though its mechanisms remain clear. The main component of this oil is eugenol, which is used as a herbal remedy for a wide variety of diseases. However, eugenol typically has a spicy odor and is effective for a limited time only, due to its volatility. We investigate the fact that unopened clove buds contain odorless eugenyl glucoside as one of the precursors of eugenol and examined the effect of eugenyl glucoside in vitro, as well as its effect on hair re-growth in vivo. Eugenol generated from eugenyl glucoside showed a much stronger 5α-reductase inhibitory effect than other related compounds and plant extracts. Further, the release of eugenol from eugenyl glucoside on human scalp showed an increase that began from just after application, and remained sustained after 24 hours. In a clinical pilot study, the efficacy rate of a hair growth agent containing 0.5% eugenyl glucoside was 83.3%. No adverse reactions were observed in any patient throughout the study period. Moreover, a 0.5% dose of eugenyl glucoside showed a mitigative effect against alcohol. From our results, we concluded that eugenyl glucoside was a useful active ingredient that showed potential as an agent for hair re-growth. |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10730 |
in IFSCC MAGAZINE > Vol. 4, N° 2 (04-05-06/2001) . - p. 83-87
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Eugenyl glucoside as an active ingredient for hair re-growth agent : release of eugenol from eugenyl glucoside on human scalp and 5alpha-reductase inhibitory effect in IFSCC MAGAZINE, Vol. 4, N° 2 (04-05-06/2001)
