[article]
| Titre : |
A review of the range of effects of niacinamide in human skin |
| Type de document : |
texte imprimé |
| Auteurs : |
Paul J. Matts, Auteur ; John. E Oblong, Auteur ; D. L. Bissett, Auteur |
| Année de publication : |
2002 |
| Article en page(s) : |
p. 285-289 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Céramides Un céramide est un sphingolipide résultant de la combinaison d'un acide gras avec la sphingosine via une liaison amide. On trouve de telles molécules en abondance dans les membranes cellulaires, où elles entrent notamment dans la constitution des sphingomyélines. Les céramides ne jouent pas qu'un rôle structurel dans les membranes biologiques, et peuvent également revêtir des fonctions de signalisation lipidique. Leurs actions les mieux comprises vont de la différenciation cellulaire à la mort cellulaire programmée (apoptose) en passant par la prolifération cellulaire.
Les acides gras qui les constituent ont généralement un nombre pair (de 16 à 24) d'atomes de carbone, sont saturés ou monoinsaturés, et sont souvent α-hydroxylés.
La plupart des céramides n'existent pas à l'état naturel si ce n'est comme précurseurs de la biosynthèse des sphingolipides par une réaction d'addition sur la fonction alcool primaire de la sphingosine. (Wikipedia)
Nicotinamide
Peau
Peau -- Soins et hygiène
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Niacinamide (also known as nicotinamide, 3-pyridinecarboxamide) is the physiologically active form of niacin or vitamin B3, the deficiency of which results in the nutritional disease pellagra with distinct cutaneous manifestations. Since its discovery and isolation, a host of dermatological therapeutic benefits and mechanisms have also been ascribed to this essential water-soluble vitamin when used as a topical agent. These include its apparent role as an anti-acne active, an up-regulator of epidermal sphingo-lipid synthesis, an up-regulator of markers of epidermal differentiation and dermal proliferation (with concurrent stratum corneum barrrier benefits), and as a moderator of photoimmune suppression and accompanying tumor genesis. More recently, fresh evidence points to a role in modifying the cosmetic appearance of skin through suppression of epidermal melanosome transfer with subsequent effect on skin pigmentation and a role in modifying epidermal surface topography. The mechanisms for these cutaneous effects are still unclear. However, since niacinamide is an important precursor of NADH and NADPH, it has been postulated that topical application of niacinamide can promote this reported broad spectrum of activity through local correction of homeostatic balance of these two nucleotide coenzymes. As there has been a dramatic increase in research into and use of niacinamide in recent years, this review will cover the current scope of knowledge of this important vitamin, including mechanistic understanding and cutaneous physiological activity. |
| Note de contenu : |
- History of niacinamide
- Physiological role of niacinamide
- Nicotinamide coenzymes in skin are depleted with age ; niacinamide can help normalize this imbalance
- Age fibroblasts secrete less collagen than young cells ; nicaninamide can stimulate new synthese
- Niacinamide up-regulates epidermal ceramide synthesis with concurrent epidermal barrier benefits
- Niacinamide up-regulates biosynthesis of markers of keratinocyte differentiation
- Niacinamide helps prevent UV-induced deleterious molecular and immunological events
- Niacinamide inhibits transfer of melanosomes from melanocytes to keratinocytes
- Regulation of sebaceous lipid and acne by niacinamide
- Niacinamide exerts multipl benefits on the appearance of ageing/photodamaged skin in-vivo
- Niacinamide is delivered effectively from a range of vehicles and demonstrates excellent skin compatibility |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10629 |
in IFSCC MAGAZINE > Vol. 5, N° 4 (10-11-12/2002) . - p. 285-289
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A review of the range of effects of niacinamide in human skin in IFSCC MAGAZINE, Vol. 5, N° 4 (10-11-12/2002)
