[article]
| Titre : |
Epidermal overexpression of stratum corneum chymotryptic enzyme, skin inflammation, and itch |
| Type de document : |
texte imprimé |
| Auteurs : |
Lennart Hansson, Auteur ; Anders Bergman, Auteur ; Annelii Ny, Auteur ; Elisabeth Ekholm, Auteur ; Torbjorn Egelrud, Auteur |
| Année de publication : |
2002 |
| Article en page(s) : |
p. 279-283 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Couche cornée
Eczéma constitutionnel
Peau -- Inflammation
Peau -- Maladies
Peptidases
Prurits
Psoriasis
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Identification of tissue-specific mechanisms involved in the pathophysiology of inflammatory skin diseases could offer new possibilities to develop effective therapies with fewer systemic effects. One of the major unmet dermatological problems is itch, which is poorly understood and often difficult to threat. Understanding skin specific targets to identify new technology to ameliorate inflammation and itching is an under researched area but should represent a major market opportunity for both the cosmetic and dermatological industries.
Stratum corneum chymotryptic enzyme (SCCE) is a serine protease, which is involved in the proteolytic degradation of corneodesmosomes during desquamation and possibly the activation of pro-inflammatory cytokines such as interleukin-1beta. SCCE is preferentially expressed in cornifying epithelia. It is synthesised by keratinocytes, packaged into the lamellar granules and extruded into the intercellular spaces in the stratum corneum together with the barrier lipids. Here we report on increased epidermal expression of SCCE in psoriasis and atopic dermatitis ; two major chronic inflammatory diseases. In atopic dermatitis, which is often associated with allergic diseases such as rhinoconjunctivitis and asthma, itch is a major symptom. We also pretent our findings on transgenic mice expressing human SCCE in suprabasal epidermal keratinocytes that developed pathologic skin changes similar to the human inflammatory diseases with increased epidermal thickness, hyperkeratosis, dermal inflammtion, impaired barrier function and severe pruritus. These findings indicate that SCCE may be involved in the pathogenesis of inflammatory skin diseases and itch, and that it should be evaluated as potential targets for new therapies. |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10628 |
in IFSCC MAGAZINE > Vol. 5, N° 4 (10-11-12/2002) . - p. 279-283
[article]
|
Aller sur edunet
Accueil
Epidermal overexpression of stratum corneum chymotryptic enzyme, skin inflammation, and itch in IFSCC MAGAZINE, Vol. 5, N° 4 (10-11-12/2002)
