[article]
| Titre : |
Characterization of surface and subsurface photodegradation of skin |
| Type de document : |
document électronique |
| Auteurs : |
Yash K. Kamath, Auteur ; Sigrid B. Ruetsch, Auteur |
| Année de publication : |
2003 |
| Article en page(s) : |
p. 199-205 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Caractérisation
Fluorimétrie
Peau -- Effet du rayonnement ultraviolet
Photovieillissement (dermatologie)
Produits antisolaires
Spectrophotométrie UV-Visible
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
In this work, fluorescence and ultraviolet spectroscopic methods have been adapted to characterize photochemical damage to skin. As opposed to the usual method of quantifying skin damage by erythema (redness), in this work we have tried to distinguish between surface and subsurface damage by applying spectroscopic methods mentioned above directly to the skin specimens. Subsurface damage, especially, is known to lead to immunosuppressive effects on the skin, sometimes resulting in skin cancer.
Because the study involves subsurface effects, this work has been done in vitro using Yutacan black pigskin as the model. Formation of photodegradation products and their suppression in the presence of sunscreens has been demonstrated microspectrophotometrically. Two types of sunscreens have been used in this study : 1)TiO2 and ZnO which deposit and remain on the skin surface without penetration; and 2) Benzophenone-4, which is water soluble and is able to penetrate into the skin. The results clearly indicate that the particulate sunscreens protect the surface of Benzophenone-4 protects the subsurface regions of viable epidermis. The results seem to support a free radical mechanism of photodamage, where free radicals are generated near the surface by the interaction of radiation with the substrate, including trace minerals, particulate sunscreens and water. These free radicals diffuse into the subsurface regions of the skin to cause damage. To prevent such damage, the sunscreen molecules capable of diffusing into the substrate should be present in those regions to scavenge the free radicals. Otherwise, subsurface damage will proceed unchecked in spite of the sunscreens on the surface. |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10557 |
in IFSCC MAGAZINE > Vol. 6, N° 3 (07-08-09/2003) . - p. 199-205
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Characterization of surface and subsurface photodegradation of skin in IFSCC MAGAZINE, Vol. 6, N° 3 (07-08-09/2003)
