[article]
| Titre : |
Comparative topical absorption and antioxidant effectiveness of two forms of coenzyme Q10 after a single dose and after long-term supplementation in the skin of young and middle-aged subjects |
| Type de document : |
texte imprimé |
| Auteurs : |
Joe Vinson, Auteur ; Sunil Anamandla, Auteur |
| Année de publication : |
2005 |
| Article en page(s) : |
p. 287-292 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Tags : |
'Coenzyme Q10' 'Peau humaine' 'Péroxydes lipidiques' Antioxydants 'Stratum corneum' |
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Coenzyme Q10 is an endogenous antioxidant found in the skin along with vitamins A, C and E. Coenzyme Q10 is used
increasingly in cosmetic products and is advertised as a skin energizer, protector against skin aging, skin repairer, and
an anti-wrinkling agent. As the outermost layer of skin, the stratum corneum is the interface between the body and
the environment and requires antioxidants to protect it and the epidermis and dermis below it. Nutrient levels in the
stratum corneum correlate with those in the skin. Two forms of coenzyme Q10 (pure coenzyme Q10 and a yeast-based
coenzyme Q10) were investigated in a commercial vehicle. Two groups of subjects were tested aged 21-29 and 51-70,
respectively. Coenzyme Q10 absorption in the stratum corneum was determined after a 1-hour application and ethanol
extraction. Significantly more yeast coenzyme Q10 was absorbed than the pure coenzyme Q10 and the middle-aged
subjects absorbed about twice as much coenzyme Q10 as did the younger subjects. Skin antioxidants were significantly
increased by yeast coenzyme Q10 but not by pure coenzyme Q10. Peroxides declined in the stratum corneum
after twice daily application of coenzyme Q10 with both forms but the decrease was greater with the yeast form. The
older subjects had significantly higher baseline levels of lipid peroxides than did the younger group, indicating an increase
in skin oxidative damage with age. The yeast coenzyme Q10 is the superior form of coenzyme Q10 for human
skin application. |
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in IFSCC MAGAZINE > Vol. 8, N° 4 (10-11-12/2005) . - p. 287-292
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Comparative topical absorption and antioxidant effectiveness of two forms of coenzyme Q10 after a single dose and after long-term supplementation in the skin of young and middle-aged subjects in IFSCC MAGAZINE, Vol. 8, N° 4 (10-11-12/2005)
