[article]
| Titre : |
Blackberry leaf extract : a multifunctional anti-aging active |
| Type de document : |
texte imprimé |
| Auteurs : |
Martina Herrmann, Auteur ; Susanne Grether-Beck, Auteur ; Imke Meyer, Auteur ; Helge Franke, Auteur ; Holger Joppe, Auteur ; Jean Krutmann, Auteur ; Gabriele Vielhaber, Auteur |
| Année de publication : |
2007 |
| Article en page(s) : |
p. 41-45 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Tags : |
'Extrait de feuille Blackberry' 'Balayage radical' 'Rubus fructicosus' 'Anti-âge' 'Mmp-1' 'Il-1?' |
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Matrix metalloproteinases (MMPs) play a major role in wrinkle formation. Their expression increases with aging and is further enhanced by UV irradiation. Blackberry (Rubus fruticosus) leaf extract has been shown to suppress MMP-1, -2 and -9 in cell-free assays. We have now further explored the activity of this extract. The effect on MMP-1 expression at the protein and the mRNA level was investigated using non-irradiated and UVA-irradiated human dermal fibroblasts. The extract showed a dose-dependent reduction of the MMP-1 protein level of both irradiated and non-irradiated cells with an almost complete inhibition at a dosage of 0.1%. MMP-1 mRNA expression of UVA-irradiated cells was decreased after pre-incubation as well as after post-incubation with the extract. Best results were obtained with combined pre- and post-treatment (0.1% extract led to 59% reduction in comparison with the respective control). Moreover, we found that blackberry leaf extract inhibits IL-1α, a cytokine known to induce MMP expression. At a dosage of 0.2% the inhibition was 40% compared with that of the stimulated control. The extract also exhibited a potent radical scavenging activity comparable to that of α-tocopherol as was shown by the ABTS assay. Taken together, these biological activities make blackberry leaf extract a highly efficient multifunctional anti-aging active. |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10428 |
in IFSCC MAGAZINE > Vol. 10, N° 1 (01-02/2007) . - p. 41-45
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Blackberry leaf extract : a multifunctional anti-aging active in IFSCC MAGAZINE, Vol. 10, N° 1 (01-02/2007)
