[article]
| Titre : |
Small proteoglycans in the skin : new targets in the fight against skin aging |
| Type de document : |
texte imprimé |
| Auteurs : |
Gilles Pauly, Auteur ; Jean-Luc Contet-Audonneau, Auteur ; Philippe Moussou, Auteur ; Louis Danoux, Auteur ; Vincent Bardey, Auteur ; Olga Freis, Auteur ; Mélanie Sabadotto, Auteur ; Yanusz Wegrowski, Auteur ; François-Xavier Maquart, Auteur ; Andreas Rathjens, Auteur |
| Année de publication : |
2008 |
| Article en page(s) : |
p. 21-29 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Tags : |
Glycosaminoglycanes Protéoglycanes Syndécane Lumicane Vieillissement |
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Proteoglycans take an important part in tissue homeostasis. In the skin, Proteoglycans are present in the extracellular matrix of dermis, particularly with lumican which plays an important role in dermal homeostasis. In the epidermis, several small proteoglycans such as the syndecans are synthesized and play an important role in keratinocyte activation. There is much data on the alteration during skin aging of the synthesis and structure of glycosaminoglycans and some proteoglycans but little information on small proteoglycans, in particular lumican and syndecan-1.
We recently observed a decrease in the synthesis of these two small proteoglycans with aging. We confirm in this work the decrease in lumican in dermis and syndecan-1 in epidermis with aging. These proteoglycans represent original important targets for cosmetology in the fight against skin aging. In different in vitro models, two synthetic acetyl tetrapeptides, AcTP1 and AcTP2, stimulate the synthesis of lumican and syndecan-1, respectively. The beneficial action of AcTP1 on skin thickness and firmness and of AcTP2 on epidermal cohesion has been confirmed in vivo. |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10385 |
in IFSCC MAGAZINE > Vol. 11, N° 1 (01-02-03/2008) . - p. 21-29
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Small proteoglycans in the skin : new targets in the fight against skin aging in IFSCC MAGAZINE, Vol. 11, N° 1 (01-02-03/2008)
